Terazosin

Terazosin
(IUPAC) ime
	(RS)-6,7-dimetoksi-2-[4-(tetrahidrofuran-2-ilkarbonil)piperazin-1-il]hinazolin-4-amin
Klinički podaci
Robne marke	Hitrin
AHFS/Drugs.com	Monografija
MedlinePlus	a693046
Identifikatori
CAS broj	63590-64-7
ATC kod	G04CA03
PubChem	5401
DrugBank	DB01162
ChemSpider	5208
UNII	8L5014XET7
KEGG	D08569
ChEBI	CHEBI:9445
ChEMBL	CHEMBL611
Hemijski podaci
Formula	C19H25N5O4
Mol. masa	387,433 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22) ; Key: VCKUSRYTPJJLNI-UHFFFAOYSA-N
Sinonimi	[4-(4-amino-6,7-dimetoksi-hinazolin-2-il)piperazin-1-il]-tetrahidrofuran-2-il-metanon
Farmakokinetički podaci
Vezivanje za proteine plazme	90-94%
Poluvreme eliminacije	12 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Terazosin (Hitrin, Zayasel) je selektivni antagonist alfa-1 adrenergičkog receptora koji se koristi za lečenje simptoma uvećane prostate (BPH). On takođe deluje tako što snižava krvni pritisak, te je stoga lek prvog izbora za osobe sa hipertenzijom i uvećanom prostatom.

On deluje putem blokiranja dejstva adrenalina na glatkim mišićima bešike i zidovima krvnih sudova.

Najčešće pojave su vrtoglavica, mamurluk, glavobolja, konstipacija, gubitak apetita, izmemoglost, nazalna kongestija ili suve oči. Ovi simptomi obično nestaju nakon nekoliko dana upotrebe. Terapija treba uvek da počne sa niskim dozama.^[6] Seksualne nuspojave se retko javljaju.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ „Hytrin (Terazosin Hcl) drug warnings and precautions - prescription drugs and medications at RxList”. Arhivirano iz originala na datum 2008-06-16. Pristupljeno 2014-04-05.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] „Hytrin (Terazosin Hcl) drug warnings and precautions - prescription drugs and medications at RxList”. Arhivirano iz originala na datum 2008-06-16. Pristupljeno 2014-04-05.

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