Arotinolol

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Arotinolol
(IUPAC) ime
(RS)-5-(2[3-(tert-butilamino)-2-hidroksipropil]sulfanil 1,3-tiazol-4-il)tiofen-2-karboksamid
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 41287-43-8
ATC kod nije dodeljen
PubChem[1][2] 2239
ChemSpider[3] 2152
UNII 394E3P3B99 YesY
KEGG[4] D07465 YesY
ChEMBL[5] CHEMBL93298 YesY
Hemijski podaci
Formula C15H21N3O2S3 
Mol. masa 371,54 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost 2 h
Poluvreme eliminacije 10 h
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Prescription only
Način primene Oralno

Arotinolol (Almarl) je lek u klasi mešovitih alfa/beta blokatora.[6]

Upotreba[uredi - уреди | uredi izvor]

On se koristi za tretman visokog krvnog pritiska.[7] Predloženo je da se on može koristiti za treatman esencijalnog tremora.[8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Zhao J, Golozoubova V, Cannon B, Nedergaard J (July 2001). "Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes". Can. J. Physiol. Pharmacol. 79 (7): 585–93. PMID 11478592. doi:10.1139/cjpp-79-7-585. 
  7. Wu H, Zhang Y, Huang J et al. (September 2001). "Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers". Hypertens. Res. 24 (5): 605–10. PMID 11675958. doi:10.1291/hypres.24.605.  - Scholar search}}
  8. Lee KS, Kim JS, Kim JW, Lee WY, Jeon BS, Kim D (August 2003). "A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor". Parkinsonism Relat. Disord. 9 (6): 341–7. PMID 12853233. doi:10.1016/S1353-8020(03)00029-4. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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