Levobunolol

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Levobunolol
(IUPAC) ime
(S)-5[3-(tert-butilamino)-2-hidroksipropil]oksi3,4-dihidronaftalen-1(2H)-on
Klinički podaci
Robne marke Betagan
AHFS/Drugs.com Monografija
MedlinePlus a686011
Identifikatori
CAS broj 47141-42-4
ATC kod S01ED03
PubChem[1][2] 39468
DrugBank DB01210
ChemSpider[3] 36089
UNII G6317AOI7K YesY
KEGG[4] D08115 YesY
ChEBI CHEBI:6438 YesY
ChEMBL[5] CHEMBL1201237 YesY
Hemijski podaci
Formula C17H25NO3 
Mol. masa 291,385 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Poluvreme eliminacije 20 sata
Farmakoinformacioni podaci
Trudnoća ?
Pravni status -only (SAD)
Način primene Topikalno (kapi za oči)

Levobunolol (AK-Beta, Liquifilm, Betegan) je neselektivni beta blokator. On se koristi topikalno za tretiranje glaukoma.

Reference[uredi - уреди | uredi kôd]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit

Literatura[uredi - уреди | uredi kôd]

  • Ishibashi T, Yokoi N, Kinoshita S (2003). „Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.”. Cornea 22 (8): 709–15. DOI:10.1097/00003226-200311000-00001. PMID 14576520. 
  • Ogasawara H, Yoshida A, Fujio N, Konno S, Ishiko S (1999). „[Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers]”. Nippon Ganka Gakkai Zasshi 103 (7): 544–50. PMID 10443129. 
  • Leung M, Grunwald J (1997). „Short-term effects of topical levobunolol on the human retinal circulation.”. Eye 11 (3): 371–6. DOI:10.1038/eye.1997.78. PMID 9373479. 

Spoljašnje veze[uredi - уреди | uredi kôd]


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