SR 59230A

SR 59230A
	(2S)-1-(2-etilfenoksi)-3-([(1S)-1,2,3, 4-tetrahidronaftalen-1-il]amino)propan-2-ol
Identifikacija
CAS registarski broj	174689-39-5
PubChem	5311452
IUPHAR ligand	547
Jmol-3D slike	Slika 1
SMILES
	CCC1=CC=CC=C1OCC(CNC2CCCC3=CC=CC=C23)O
Svojstva
Molekulska formula	C21H27NO2
Molarna masa	325.44 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

SR 59230A je selektivni antagonist beta-3 adrenergičkog receptora.^[3]^[4]^[5] On isto tako deluje na α₁ adrenoceptorima pri visokim dozama.^[6] On blokira hipertermiju proizvedenu putem MDMA u životinjskim studijama.^[7]

Reference[uredi - уреди | uredi izvor]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1.
↑ Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective β₃-adrenergic receptor antagonist SR 59230A in rat brown adipocytes". Mol. Pharmacol. 49 (1): 7–14. PMID 8569714.
↑ Bellantuono V, Cassano G, Lippe C (August 2008). "The adrenergic receptor subtypes present in frog (Rana esculenta) skin". Comp. Biochem. Physiol. C Toxicol. Pharmacol. 148 (2): 160–4. PMID 18544474. doi:10.1016/j.cbpc.2008.05.001.
↑ Rickenbacher A, Seiler R, Honegger U, Shaw SG, Balsiger BM (January 2008). "Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation". Surgery 143 (1): 94–102. PMID 18154937. doi:10.1016/j.surg.2007.06.034.
↑ Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B (April 2004). "Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery". J. Pharmacol. Exp. Ther. 309 (1): 137–45. PMID 14718590. doi:10.1124/jpet.103.061192.
↑ Bexis S, Docherty JR (April 2009). "Role of alpha(1)- and beta(3)-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse". British Journal of Pharmacology 158 (1): 259–66. PMC 2795232. PMID 19422394. doi:10.1111/j.1476-5381.2009.00186.x.

Spoljašnje veze[uredi - уреди | uredi izvor]

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1.

[pmid8569714-3] Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective β₃-adrenergic receptor antagonist SR 59230A in rat brown adipocytes". Mol. Pharmacol. 49 (1): 7–14. PMID 8569714.

[pmid18544474-4] Bellantuono V, Cassano G, Lippe C (August 2008). "The adrenergic receptor subtypes present in frog (Rana esculenta) skin". Comp. Biochem. Physiol. C Toxicol. Pharmacol. 148 (2): 160–4. PMID 18544474. doi:10.1016/j.cbpc.2008.05.001.

[pmid18154937-5] Rickenbacher A, Seiler R, Honegger U, Shaw SG, Balsiger BM (January 2008). "Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation". Surgery 143 (1): 94–102. PMID 18154937. doi:10.1016/j.surg.2007.06.034.

[pmid14718590-6] Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B (April 2004). "Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery". J. Pharmacol. Exp. Ther. 309 (1): 137–45. PMID 14718590. doi:10.1124/jpet.103.061192.

[pmid19422394-7] Bexis S, Docherty JR (April 2009). "Role of alpha(1)- and beta(3)-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse". British Journal of Pharmacology 158 (1): 259–66. PMC 2795232. PMID 19422394. doi:10.1111/j.1476-5381.2009.00186.x.

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SR 59230A

Reference[uredi - уреди | uredi izvor]

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