SR 59230A

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SR 59230A
SR 59230A.svg
IUPAC ime
Identifikacija
CAS registarski broj 174689-39-5
PubChem[1][2] 5311452
IUPHAR ligand 547
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C21H27NO2
Molarna masa 325.44 g mol−1

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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

SR 59230A je selektivni antagonist beta-3 adrenergičkog receptora.[3][4][5] On isto tako deluje na α1 adrenoceptorima pri visokim dozama.[6] On blokira hipertermiju proizvedenu putem MDMA u životinjskim studijama.[7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes". Mol. Pharmacol. 49 (1): 7–14. PMID 8569714. 
  4. Bellantuono V, Cassano G, Lippe C (August 2008). "The adrenergic receptor subtypes present in frog (Rana esculenta) skin". Comp. Biochem. Physiol. C Toxicol. Pharmacol. 148 (2): 160–4. PMID 18544474. doi:10.1016/j.cbpc.2008.05.001. 
  5. Rickenbacher A, Seiler R, Honegger U, Shaw SG, Balsiger BM (January 2008). "Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation". Surgery 143 (1): 94–102. PMID 18154937. doi:10.1016/j.surg.2007.06.034. 
  6. Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B (April 2004). "Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery". J. Pharmacol. Exp. Ther. 309 (1): 137–45. PMID 14718590. doi:10.1124/jpet.103.061192. 
  7. Bexis S, Docherty JR (April 2009). "Role of alpha(1)- and beta(3)-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse". British Journal of Pharmacology 158 (1): 259–66. PMC 2795232. PMID 19422394. doi:10.1111/j.1476-5381.2009.00186.x. 

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