Labetalol
Prijeđi na navigaciju
Prijeđi na pretragu
![]() | |||
(IUPAC) ime | |||
---|---|---|---|
(RS)-2-hidroksi-51-hidroksi-2-[(1-metil-3-fenolpropil)amino]etil}benzamid | |||
Klinički podaci | |||
Robne marke | Trandat | ||
AHFS/Drugs.com | Monografija | ||
MedlinePlus | a685034 | ||
Identifikatori | |||
CAS broj | 36894-69-6 | ||
ATC kod | C07AG01 | ||
PubChem[1][2] | 3869 | ||
DrugBank | DB00598 | ||
ChemSpider[3] | 3734 | ||
UNII | R5H8897N95 ![]() | ||
KEGG[4] | D08106 ![]() | ||
ChEBI | CHEBI:6343 ![]() | ||
ChEMBL[5] | CHEMBL429 ![]() | ||
Hemijski podaci | |||
Formula | C19H24N2O3 | ||
Mol. masa | 328,406 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakokinetički podaci | |||
Bioraspoloživost | 25% | ||
Vezivanje za proteine plazme | 50% | ||
Metabolizam | hepatički | ||
Poluvreme eliminacije | Tableta: 6-8 sati; IV: 5.5 sati | ||
Izlučivanje | urin | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | ℞ Prescription only | ||
Način primene | oralno iv |
Labetalol (Normodin, Trandat) je mešoviti alfa/beta adrenergički antagonist, koji se koristi za tretiranje visokog krvnog pritiska.[6]
Indikcije[uredi | uredi kod]
Koristi se kao tretman trudnoćom indukovanu hipertenziju koja je često vezana za preeklampsiju.[7] On se takođe koristi za tretiranje hronične i akutne hipertenzije feohromocitoma i hipertenzivne krize.[8][9]
Stereokemija[uredi | uredi kod]
Labetalol sadrži dva stereogena centra i sastoji se od četiri stereoizomera. Ovo je mješavina ("R", "R") -, ("S", "R") -, ("R", "S" ) - i ( S , S ) - oblik:
Stereoizomeri Labetalola | |
---|---|
![]() CAS-Nummer: 75659-07-3 |
![]() CAS-Nummer: 83167-24-2 |
![]() CAS-Nummer: 83167-32-2 |
![]() CAS-Nummer: 83167-31-1 |
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Fahed S, Grum DF, Papadimos TJ (2008). „Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety”. Patient Saf Surg 2: 13. DOI:10.1186/1754-9493-2-13. PMC 2429901. PMID 18505576.
- ↑ C. J. Pickles, E. M. Symonds, F. Broughton Pipkin (January 1989). „The fetal outcome in a randomized double-blind controlled trial of labetalol versus placebo in pregnancy-induced hypertension”. BJOG: An International Journal of Obstetrics & Gynaecology 96 (1): 38–43. DOI:10.1111/j.1471-0528.1989.tb01574.x.
- ↑ Katzung, Bertram G. (2006). Basic and clinical pharmacology. New York: McGraw-Hill Medical. str. 170. ISBN 0-07-145153-6.
- ↑ D A Richards, J Tuckman, and B N Prichard (October 1976). „Assessment of alpha- and beta-adrenoceptor blocking actions of labetalol”. Br J Clin Pharmacol 3 (5): 849–855. PMC 1428931. PMID 9968.
Literatura[uredi | uredi kod]
Spoljašnje veze[uredi | uredi kod]
![]() |
Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini). |