Dihloroizoprenalin

Dihloroizoprenalin
	Preferentno IUPAC ime Dihloroizoprenalin
Naziv po klasifikaciji	1-(3,4-Dihlorofenil)-2-[(propan-2-il)amino]etan-1-ol
Drugi nazivi	1-(3,4-Dihlorofenil)-2-(izopropilamino)etanol; Dihlorizoproterenol
Identifikacija
CAS registarski broj	59-61-0
PubChem	5806 (1R), ; 6951395 (1S), ; 5806 ()
ChemSpider	5601 (1R) , 5324297 (1S) , 5601 ()
KEGG	C11772
MeSH	Dichloroisoproterenol
ChEBI	144234
ChEMBL	CHEMBL30816
Jmol-3D slike	Slika 1; Slika 2
SMILES
	CC(C)NCC(O)C1=CC(Cl)=C(Cl)C=C1 Clc1ccc(cc1Cl)C(O)CNC(C)C
InChI
	InChI=1S/C11H15Cl2NO/c1-7(2)14-6-11(15)8-3-4-9(12)10(13)5-8/h3-5,7,11,14-15H,6H2,1-2H3 ; Kod: VKMGSWIFEHZQRS-UHFFFAOYSA-N InChI=1/C11H15Cl2NO/c1-7(2)14-6-11(15)8-3-4-9(12)10(13)5-8/h3-5,7,11,14-15H,6H2,1-2H3; Kod: VKMGSWIFEHZQRS-UHFFFAOYAS
Svojstva
Molekulska formula	C11H15Cl2NO
Molarna masa	248,15 g/mol
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Dihloroizoprenalin (DCI, dihlorosisoproterenol) je bio prvi beta blokator ikad razvijen. On je neselektivan za β₁-adrenergički i β₂-adrenergički receptor. DCI ima nisku potentnost i deluje kao parcijalni agonist/antagonist na tim receptorima.^[6]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ W. E. Glover, A. D. M. Greenfield, and R. G. Shanks (1962). „Effect of dichloroisoprenaline on the peripheral vascular responses to adrenaline in man”. Br J Pharmacol Chemother 19: 235–244. PMC 1482134.

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