Dihloroizoprenalin

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Dihloroizoprenalin
Dichloroisoprenaline.svg
Naziv po klasifikaciji 1-(3,4-Dihlorofenil)-2-[(propan-2-il)amino]etan-1-ol
Drugi nazivi 1-(3,4-Dihlorofenil)-2-(izopropilamino)etanol
Dihlorizoproterenol
Identifikacija
CAS registarski broj 59-61-0 YesY
PubChem[1][2] 5806 (1R), 
6951395 (1S), 
5806 ()
ChemSpider[3] 5601 (1R) YesY, 5324297 (1S) YesY, 5601 () YesY
KEGG[4] C11772
MeSH Dichloroisoproterenol
ChEBI 144234
ChEMBL[5] CHEMBL30816 YesY
Jmol-3D slike Slika 1
Slika 2
Svojstva
Molekulska formula C11H15Cl2NO
Molarna masa 248,15 g/mol

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Dihloroizoprenalin (DCI, dihlorosisoproterenol) je bio prvi beta blokator ikad razvijen. On je neselektivan za β1-adrenergički i β2-adrenergički receptor. DCI ima nisku potentnost i deluje kao parcijalni agonist/antagonist na tim receptorima.[6]

Dihloroizoprenalin je racemska smeša enantiomera.

Dva enantiomera dihloroizoprenalina

Reference[uredi - уреди | uredi kôd]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. W. E. Glover, A. D. M. Greenfield, and R. G. Shanks (1962). „Effect of dichloroisoprenaline on the peripheral vascular responses to adrenaline in man”. Br J Pharmacol Chemother 19: 235–244. PMC 1482134. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482134/. 

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