Gvanabenz

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Gvanabenz
(IUPAC) ime
2-(2,6-dihlorobenziliden)hidrazinkarboksimidamid
Klinički podaci
AHFS/Drugs.com Potrošačka informacije o leku
MedlinePlus a686003
Identifikatori
CAS broj 5051-62-7
ATC kod nije dodeljen
PubChem[1][2] 5702063
DrugBank DB00629
ChemSpider[3] 4642445
UNII GGD30112WC YesY
KEGG[4] D04375 YesY
ChEMBL[5] CHEMBL420 YesY
Hemijski podaci
Formula C8H8Cl2N4 
Mol. masa 231,081 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Vezivanje za proteine plazme 90%
Poluvreme eliminacije 6 sata
Farmakoinformacioni podaci
Trudnoća C(US)
Pravni status

Guanabenz (Wytensin) je alfa agonist alfa-2 tipa koji se koristi kao antihipertenzivni lek. On se upotrebljava za tretiranje visokog krvnog pritiska (hipertenzije).[6][7]

Najčešće nuspojava tomo njegove upotrebe su nesvestica, pospanost, suva usta, glavobolja i slabost.

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Walker BR, Hare LE, Deitch MW (1982). "Comparative antihypertensive effects of guanabenz and clonidine". The Journal of International Medical Research 10: 6–14. PMID 7037502. 
  7. Bonham AC, Trapani AJ, Portis LR, Brody MJ (1984). "Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine". Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension 2: S543–6. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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