Guanabenz (Wytensin ) je alfa agonist alfa-2 tipa koji se koristi kao antihipertenzivni lek. On se upotrebljava za tretiranje visokog krvnog pritiska (hipertenzije ).[6] [7]
Najčešće nuspojava tomo njegove upotrebe su nesvestica , pospanost , suva usta , glavobolja i slabost .
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery." . Drug Discov Today 15 (23-24): 1052–7. PMID 20970519 . doi :10.1016/j.drudis.2010.10.003 . edit ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4 : 217–241. doi :10.1016/S1574-1400(08)00012-1 . ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining" . J Cheminform 2 (1): 3. PMID 20331846 . doi :10.1186/1758-2946-2-3 . edit ↑ Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG" . Yeast 17 (1): 48–55. doi :10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H . ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594 . doi :10.1093/nar/gkr777 . edit ↑ Walker BR, Hare LE, Deitch MW (1982). "Comparative antihypertensive effects of guanabenz and clonidine" . The Journal of International Medical Research 10 : 6–14. PMID 7037502 . ↑ Bonham AC, Trapani AJ, Portis LR, Brody MJ (1984). "Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine" . Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension 2 : S543–6.
Agonisti :
5-FNE •
6-FNE •
Amidefrin •
Anisodamin •
Anisodin •
Cirazolin •
Dipivefrin •
Dopamin •
Efedrin •
Epinefrin (Adrenalin) •
Etilefrin •
Etilnorepinefrin •
Indanidin •
Levonordefrin •
Metaraminol •
Metoksamin •
Metildopa •
Midodrin •
Nafazolin •
Norepinefrin (Noradrenalin) •
Oktopamin •
Oksimetazolin •
Fenilefrin •
Fenilpropanolamin •
Pseudoefedrin •
Sinefrin •
Tetrahidrozolin
Antagonisti :
Abanohil •
Adimolol •
Ajmalicin •
Alfuzosin •
Amosulalol •
Arotinolol •
Atiprosin •
Benoksatian •
Buflomedil •
Bunazosin •
Karvedilol •
CI-926 •
Korinantin •
Dapiprazol •
DL-017 •
Domesticin •
Doksazosin •
Eugenodilol •
Fenspirid •
GYKI-12,743 •
GYKI-16,084 •
Indoramin •
Ketanserin •
L-765,314 •
Labetalol •
Mefendioksan •
Metazosin •
Monatepil •
Moksisilit (Timoksamin) •
Naftopidil •
Nantenin •
Neldazosin •
Nicergolin •
Niguldipin •
Pelanserin •
Fendioksan •
Fenoksibenzamin •
Fentolamin •
Piperoksan •
Prazosin •
Hinazosin •
Ritanserin •
RS-97,078 •
SGB-1,534 •
Silodosin •
SL-89.0591 •
Spiperon •
Talipeksol •
Tamsulosin •
Terazosin •
Tibalosin •
Tiodazosin •
Tipentosin •
Tolazolin •
Trimazosin •
Upidosin •
Urapidil •
Zolertin
* Mnogi TCA , TeCA , antipsihotici , ergolini , i neki piperazini kao što su buspiron , trazodon , nefazodon , etoperidon , i mepiprazol takođe antagoniziraju α1 -adrenergičke receptore, što doprinosi njihovim nuspojavama.
Molimo Vas, obratite pažnju na važno upozorenje zdravlju (medicini) .
