Nitrazepam
Prijeđi na navigaciju
Prijeđi na pretragu
![]() | |||
![]() | |||
(IUPAC) ime | |||
---|---|---|---|
7-nitro-5-fenil-2,3-dihidro-1H-1,4-benzodiazepin-2-on | |||
Klinički podaci | |||
Robne marke | Alodorm, Apo-nitrazepam tablets BP, Apodorm, Benzalin | ||
AHFS/Drugs.com | Monografija | ||
Identifikatori | |||
CAS broj | 146-22-5 | ||
ATC kod | N05CD03 , N05CD02 | ||
PubChem[1][2] | 4506 | ||
DrugBank | DB01595 | ||
ChemSpider[3] | 4350 | ||
KEGG[4] | C07487 ![]() | ||
Hemijski podaci | |||
Formula | C15H11N3O3 | ||
Mol. masa | 281.2661 | ||
SMILES | eMolekuli & PubHem | ||
| |||
Fizički podaci | |||
Tačka topljenja | 225 °C (437 °F) | ||
Farmakokinetički podaci | |||
Poluvreme eliminacije | 15-38 sati | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | |||
Način primene | Oralno |
Nitrazepam je benzodiazepinski derivat koji se koristi kao antikonvulsant i hipnotik.[5][6][7][8][9][10][11]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. PMID 2883820
- ↑ Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. PMID 7782744
- ↑ Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. PMID 2570451
- ↑ Podhorna J, Krsiak M: Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice. Behav Pharmacol. 2000 Apr;11(2):143-51. PMID 10877119
- ↑ Nowakowska E, Chodera A: Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats. Pharmacol Biochem Behav. 1991 Feb;38(2):265-6. PMID 1676167
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Nucleic Acids Res (2008). DrugBank: a knowledgebase for drugs, drug actions and drug targets. 36. pp. D901-6. PMID 18048412.