Esmolol

Esmolol
(IUPAC) ime
	metil (RS)-34-[2-hidroksi-3-(propan-2-ilamino)propoksi]fenil}propanoat
Klinički podaci
AHFS/Drugs.com	Monografija
Identifikatori
CAS broj	103598-03-4
ATC kod	C07AB09
PubChem	59768
DrugBank	DB00187
ChemSpider	53916
UNII	MDY902UXSR
KEGG	D07916
ChEBI	CHEBI:4856
ChEMBL	CHEMBL768
Hemijski podaci
Formula	C16H25NO4
Mol. masa	295,374 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H25NO4/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3 ; Key: AQNDDEOPVVGCPG-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	-
Vezivanje za proteine plazme	60%
Metabolizam	Eritrociti
Poluvreme eliminacije	9 minuta
Izlučivanje	Renalno
Farmakoinformacioni podaci
Trudnoća	C(AU) C(US)
Pravni status
Način primene	IV

Esmolol (Brevibloc) je kardioselektivni blokator beta₁ receptora sa brzim početkom dejstva,^[6] i veoma kratkim trajanjem. On nema značajno intrinsično simpatomimetično ili membransko stabilišuće dejstvo pri terapeutskim dozama. On je antiaritmik iz klase II.^[7]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Deng CY, Lin SG, Zhang WC i dr.. (December 2006). „Esmolol inhibits Na+ current in rat ventricular myocytes”. Methods Find Exp Clin Pharmacol 28 (10): 697–702. DOI:10.1358/mf.2006.28.10.1037498. PMID 17235414.
↑ Jaillon P, Drici M (December 1989). „Recent antiarrhythmic drugs”. Am. J. Cardiol. 64 (20): 65J–69J. DOI:10.1016/0002-9149(89)91203-4. PMID 2688391.

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid17235414-6] Deng CY, Lin SG, Zhang WC i dr.. (December 2006). „Esmolol inhibits Na+ current in rat ventricular myocytes”. Methods Find Exp Clin Pharmacol 28 (10): 697–702. DOI:10.1358/mf.2006.28.10.1037498. PMID 17235414.

[pmid2688391-7] Jaillon P, Drici M (December 1989). „Recent antiarrhythmic drugs”. Am. J. Cardiol. 64 (20): 65J–69J. DOI:10.1016/0002-9149(89)91203-4. PMID 2688391.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Esmolol

Reference[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]

Navigacija