Atenolol

Atenolol
(IUPAC) ime
	(RS)-24-[2-Hidroksi-3-(propan-2-ilamino)propoksi]fenil}acetamid
Klinički podaci
Robne marke	Tenormin
AHFS/Drugs.com	Monografija
MedlinePlus	a684031
Identifikatori
CAS broj	29122-68-7
ATC kod	C07AB03
PubChem	2249
DrugBank	DB00335
ChemSpider	2162
UNII	50VV3VW0TI
KEGG	D00235
ChEBI	CHEBI:2904
ChEMBL	CHEMBL24
Hemijski podaci
Formula	C14H22N2O3
Mol. masa	266,336 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18) ; Key: METKIMKYRPQLGS-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	40-50%
Vezivanje za proteine plazme	6-16%
Metabolizam	Hepatički <10%
Poluvreme eliminacije	6-7 sata
Izlučivanje	Renalno; laktacijom
Farmakoinformacioni podaci
Licenca	US FDA:link
Trudnoća	C(AU) D(US)
Pravni status	℞ Prescription only
Način primene	Oralno ili IV

Atenolol (u Srbiji poznat pod zaštićenim nazivom Prinorm) je selektivni antagonist β₁ receptor. Ovaj lek pripada grupi beta blokatora (β-blokatora). Ta klasa lekova se prvenstveno koristi za kardiovaskularne bolesti. Uveden je 1976. Atenolol je razvijen kao zamena za propranolol u tretmanu hipertenzije. Ovaj lek deluje putem usporavanja srca i redukovanja njegovog opteraćenja. Za razliku od propranolola, atenolol ne prolazi kroz krvno–moždanu barijeru, čime se izbegavaju razne nuspojave u centralnom nervnom sistemu.^[6]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Agon P, Goethals P, Van Haver D, Kaufman JM (August 1991). „Permeability of the blood–brain barrier for atenolol studied by positron emission tomography”. J. Pharm. Pharmacol. 43 (8): 597–600. DOI:10.1111/j.2042-7158.1991.tb03545.x. PMID 1681079.

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

Atenolol

Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[BBB-6] Agon P, Goethals P, Van Haver D, Kaufman JM (August 1991). „Permeability of the blood–brain barrier for atenolol studied by positron emission tomography”. J. Pharm. Pharmacol. 43 (8): 597–600. DOI:10.1111/j.2042-7158.1991.tb03545.x. PMID 1681079.

[1]

[2]

[3]

[4]

[5]

[6]

Atenolol

Reference[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]

Navigacija