Ehinopsidin
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| (IUPAC) ime | |||
|---|---|---|---|
| 1-Metil-2,3-dihidrohinolin-4-imin | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 2400-75-1 58916-73-7 (hidrojodid) | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 161462 | ||
| ChemSpider[3] | 141825 | ||
| Hemijski podaci | |||
| Formula | C10H12N2 | ||
| Mol. masa | 160,22 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Sinonimi | Ehinopsidin Jodid | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | ℞ Prescription only | ||
| Način primene | Oralno | ||
Ehinopsidin (Adepren) je antidepresiv koji je korišćen u Bugarskoj za tretiranje depresije.[4][5] On povišava nivoe serotonina, norepinefrina, i dopamina u mozgu i smatra se da deluje kao inhibitor monoaminske oksidaze (MAOI).[6][7][8] Ehinopsidin se prirodno javlja u Echinops echinatus zajedno sa srodnim alkaloidima ehinopsinom i ehinozolinonom.[9]
Reference[uredi - уреди | uredi izvor]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3.
- ↑ Guliamov MG (1982). "[Experience with the use of new Bulgarian psychotropic drugs]" (Russian). Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952) 82 (11): 115–22. PMID 6758442.
- ↑ Guliamov MG (1986). "[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit]" (Russian). Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952) 86 (4): 582–7. PMID 3716711.
- ↑ Tiutiulkova N, Gorancheva Iu (1978). "[Effect of adepren on the cerebral concentration of serotonin]" (Bulgarian). Eksperimentalna Meditsina I Morfologiia 17 (2): 83–5. PMID 658004.
- ↑ Stefanova D, Tiutiulkova N, Nikolova M (1976). "[Effect of adepren on the behavior and brain catecholamines of rats in an open field setup]" (Bulgarian). Eksperimentalna Meditsina I Morfologiia 15 (1): 42–6. PMID 1269462.
- ↑ Tiutiulkova NI, Gorancheva IuI (1975). "[Excretion of dopamine, noradrenaline, adrenaline, vanilmandelic acid and 5-hydroxyindoleacetic acid in the urine of volunteers treated with adepren]" (Bulgarian). Eksperimentalna Meditsina I Morfologiia 14 (4): 187–9. PMID 1222713.
- ↑ Indian Medicinal Plants An Illustrated Dictionary. Springer-Verlag Berlin Heidelberg. 2007. ISBN 0-387-70637-2. http://books.google.com/books?id=gMwLwbUwtfkC&lpg=PA230&dq=Echinopsidine&as_brr=3&pg=PA230#v=onepage&q=&f=false.
Литература[uredi - уреди | uredi izvor]
- Indian Medicinal Plants An Illustrated Dictionary. Springer-Verlag Berlin Heidelberg. 2007. ISBN 0-387-70637-2. http://books.google.com/books?id=gMwLwbUwtfkC&lpg=PA230&dq=Echinopsidine&as_brr=3&pg=PA230#v=onepage&q=&f=false.
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