Mosaprid

Iz Wikipedije, slobodne enciklopedije
Mosaprid
(IUPAC) ime
(RS)-4-amino-5-hloro-2-etoksi-N[4-(4-fluorobenzil)morfolin-2-il]metil}benzamid
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 112885-41-3
ATC kod nije dodeljen
PubChem[1][2] 119584
ChemSpider[3] 106780
UNII I8MFJ1C0BY YesY
KEGG[4] D08236 YesY
ChEMBL[5] CHEMBL60889 YesY
Hemijski podaci
Formula C21H25ClFN3O3 
Mol. masa 421,893 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Mosaprid je gastroprokinetički agens koji deluje kao selektivni 5HT4 agonist[6] koji ubrzava gastrično pražnjenje i koristi se za tretman kiselinskog refluksa[7], sindroma iritabilnih creva i funkcionalnu dispepsiju.[8] Njegova česta sporedna dejstva su dijareja, abdomenalni bol, vrtoglavica, konstipacija, glavobolja, insomnija, i mučnina.[9]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Kato S, Morie T, Yoshida N. Synthesis and biological activities of metabolites of mosapride, a new gastroprokinetic agent. Chemical and Pharmaceutical Bulletin (Tokyo). 1995 Apr;43(4):699-702.
  7. Ruth M, Hamelin B, Rohss K, Lundell L. The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics. 1998 Jan;12(1):35-40.
  8. Mizuta Y, Shikuwa S, Isomoto H, Mishima R, Akazawa Y, Masuda J, Omagari K, Takeshima F, Kohno S. Recent insights into digestive motility in functional dyspepsia. Journal of Gastroenterology. 2006 Nov;41(11):1025-40.
  9. Mosapride drug information - Drugs Update India

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