Izamoltan

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Izamoltan
(IUPAC) ime
1-(propan-2-ilamino)-3-(2-pirol-1-ilfenoksi)propan-2-ol
Klinički podaci
Identifikatori
CAS broj 99740-06-4
ATC kod nije dodeljen
PubChem[1][2] 127403
ChemSpider[3] 113051
Hemijski podaci
Formula C16H22N2O2 
Mol. masa 274,357 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Izamoltan (CGP-361A) je lek koji se koristi u naučnim istraživanjima. On deluje kao antagonist β-adrenergičkog, 5-HT1A, i 5-HT1B receptora. On je oko pet puta potentniji na 5-HT1B receptoru (21 nmol/l) u odnosu na 5-HT1A receptor (112 nmol/l).[4] On ima anksiolitičko dejstvo na glodarima.[5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Rényi L, Larsson LG, Berg S, Svensson BE, Thorell G, Ross SB. (1991). "Biochemical and behavioural effects of isamoltane, a beta-adrenoceptor antagonist with affinity for the 5-HT1B receptor of rat brain.". Naunyn Schmiedebergs Arch Pharmacol. 343 (1): 1–6. PMID 1674359. 
  5. Waldmeier PC, Williams M, Baumann PA, Bischoff S, Sills MA, Neale RF. (1988). "Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain.". Naunyn Schmiedebergs Arch Pharmacol. 337 (6): 609–620. PMID 2905765. 

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