Atiprosin

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Atiprosin
(IUPAC) ime
(4aR,12bS)-1-etil-12-metil-4-(propan-2-il)-1,2,3,4,4a,5,6,12b-oktahidropirazino[2',3':3,4]pirido[1,2-a]indol
Klinički podaci
Identifikatori
CAS broj 89303-63-9
ATC kod nije dodeljen
PubChem[1][2] 71770
ChemSpider[3] 64808
UNII ALS52889WF YesY
Hemijski podaci
Formula C20H29N3 
Mol. masa 311,46 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Nije kontrolisan
Način primene Oralno

Atiprosin (AY-28,228) je antihipertenzivni lek koji se koristi kao selektivni antagonist α1-adrenergičkog receptora.[4][5][6][7] On takođe poseduje izvesnu antihistaminsku aktivnost, mada je ona slaba.[6] On nije plasiran na tržište.[4]

Sinteza[uredi - уреди | uredi izvor]

Jedan od mogućih sintetičkih puteva je[8]:

Atiprosin.png

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. 4,0 4,1 Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. http://books.google.com/?id=DeX7jgInYFMC&lpg=PA189&dq=atiprosin&pg=PA189#v=onepage&q. 
  5. Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry 30 (2): 388–94. PMID 3806618. doi:10.1021/jm00385a022. 
  6. 6,0 6,1 Grimes D, Rimele TJ, Henry DE et al. (September 1987). "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology 10 (3): 249–58. PMID 2444771. doi:10.1097/00005344-198709000-00001. 
  7. Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology 10 (3): 341–9. PMID 2444784. doi:10.1097/00005344-198709000-00014. 
  8. Jirkovsky, Ivo; George Santroch, Reinhardt Baudy, George Oshiro (1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medical Chemistry 30 (2): 388–394. PMID 3806618. doi:10.1021/jm00385a022. 

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