Pronetalol

Pronethalol
(IUPAC) ime
	1-(naftalen-2-il)-2-(propan-2-ilamino)etanol
Klinički podaci
Identifikatori
CAS broj	51-02-5
ATC kod	nije dodeljen
PubChem	4930
ChemSpider	4761
UNII	XBP4RT1IMQ
Hemijski podaci
Formula	C15H19NO
Mol. masa	229,32 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C15H19NO/c1-11(2)16-10-15(17)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11,15-17H,10H2,1-2H3 ; Key: HRSANNODOVBCST-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Razvoj je prekinut
Način primene	Oralno

Pronethalol (Alderlin, Netalid) je bio klinički kandidat koji deluje kao neselektivni beta blokator. On nije dospeo do kliničkih istraživanja usled karcinogenosti na miševima, koja se smatra da je rezultat formiranja karcinogenih naftalen epoksidnih metabolita.^[4]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Stapleton MP (1997). „Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology”. Tex Heart Inst J 24 (4): 336–42. PMC 325477. PMID 9456487.

Povezano

Beta blokator

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Stapleton MP (1997). „Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology”. Tex Heart Inst J 24 (4): 336–42. PMC 325477. PMID 9456487.

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