(R)-3-Nitrobifenilin

Iz Wikipedije, slobodne enciklopedije
Idi na navigaciju Idi na pretragu
(R)-3-Nitrobifenilin
(IUPAC) ime
(R)-2-[1-(3'-Nitrobifenil-2-iloksi)etil]-4,5-dihidro-1H-imidazol
Klinički podaci
MedlinePlus a682611
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 16757089
ChemSpider[3] 23288036
ChEMBL[4] CHEMBL242693 YesY
Hemijski podaci
Formula C17H17N3O3 
Mol. masa 311,334 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

(R)-3-Nitrobifenilin je lek koji deluje kao α2-adrenergički agonist. On je selektivan za α2C tip receptora. On je isto tako slab antagonist na α2A i α2B tipovima.[5]

Reference[uredi - уреди | uredi kôd]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Crassous PA, Cardinaletti C, Carrieri A, Bruni B, Di Vaira M, Gentili F, Ghelfi F, Giannella M, Paris H, Piergentili A, Quaglia W, Schaak S, Vesprini C, Pigini M (August 2007). „Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist”. Journal of Medicinal Chemistry 50 (16): 3964–8. DOI:10.1021/jm061487a. PMID 17630725. 

Spoljašnje veze[uredi - уреди | uredi kôd]