6-Fluoronorepinefrin
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 4-(2-amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 86820-21-5 | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 1862 | ||
| ChemSpider[3] | 1792 | ||
| ChEMBL[4] | CHEMBL281232 
| ||
| Hemijski podaci | |||
| Formula | C8H10FNO3 | ||
| Mol. masa | 187.17 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
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| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | nije kontrolisan | ||
6-Fluoronorepinefrin (6-FNE) je selektivni puni agonist α1- i α2-adrenergičkih receptora, koji je srodan sa norepinefrinom.[5][5][6] On je jedini poznati selektivni puni agonist α-adrenergičkih receptora. Bio je korišten u izučavanju funkcije tih receptora.[6] Infuzija 6-FNE u locus coeruleus glodara proizvodi primetnu hiperaktivnost i disinhibiciju ponašanja.[6][7]
Literatura[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ 5,0 5,1 Kirk KL, Cantacuzene D, Nimitkitpaisan Y, et al. (December 1979). „Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines”. Journal of Medicinal Chemistry 22 (12): 1493–7. PMID 231654.
- ↑ 6,0 6,1 6,2 Stone EA, Lin Y, Sarfraz Y, Quartermain D (September 2009). „Marked behavioral activation from inhibitory stimulation of locus coeruleus alpha1-adrenoceptors by a full agonist”. Brain Research 1291: 21–31. DOI:10.1016/j.brainres.2009.07.049. PMID 19632210.
- ↑ Stone EA, Grunewald GL, Lin Y, et al. (July 2003). „Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice”. Synapse (New York, N.Y.) 49 (1): 67–76. DOI:10.1002/syn.10212. PMID 12710017.