Nantenin

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Nantenin
(IUPAC) ime
(S)-1,2-Dimetoksi-6-metil-5,6,6a,7-tetrahidro-4H-benzo[de][1,3]benzodioksolo[5,6-g]quinolin
Klinički podaci
Identifikatori
CAS broj 2565-01-7
ATC kod nije dodeljen
PubChem[1][2] 197001
ChEMBL[3] CHEMBL467094 YesY
Hemijski podaci
Formula C20H21NO4 
Mol. masa 339,385 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Nantenin je alkaloid nađen u biljci Nandina domestica[4] kao i u nekim Corydalis vrstama.[5] On je antagonist α1 adrenergičkog receptroa[6] i 5-HT2A serotoninskog receptora,[7] i blokira bihevioralne i fiziološke efekte MDMA kod životinja.[8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. Shoji N, Umeyama A, Takemoto T, Ohizumi Y (April 1984). "Serotonergic receptor antagonist from Nandina domestica Thunberg". Journal of Pharmaceutical Sciences 73 (4): 568–70. PMID 6726648. doi:10.1002/jps.2600730435. 
  5. Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L (March 1982). "Alkaloids of Corydalis slivenensis". Planta Medica 44 (3): 168–70. PMID 17402105. doi:10.1055/s-2007-971432. 
  6. Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Ohizumi Y (February 2002). "Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity". European Journal of Pharmacology 437 (3): 173–8. PMID 11890906. doi:10.1016/S0014-2999(02)01303-1. 
  7. Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW (May 2009). "(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners". Bioorganic & Medicinal Chemistry Letters 19 (9): 2530–2. PMC 2677726. PMID 19328689. doi:10.1016/j.bmcl.2009.03.048. 
  8. Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH (May 2004). "Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice". Psychopharmacology 173 (3-4): 270–7. PMID 14740148. doi:10.1007/s00213-003-1741-2. 

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