Praktolol

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Praktolol
(IUPAC) ime
(RS)-N- {4-[2-hidroksi-3-(izopropilamino)propoksi]fenil}acetamid
Klinički podaci
Identifikatori
CAS broj 6673-35-4
ATC kod C07AB01
PubChem[1][2] 4883
DrugBank DB01297
ChemSpider[3] 4715
UNII SUG9176GRW YesY
KEGG[4] D05587 YesY
ChEBI CHEBI:258351 YesY
ChEMBL[5] CHEMBL6995 YesY
Hemijski podaci
Formula C14H22N2O3 
Mol. masa 266,336 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Practolol (Eraldin, Dalzic, Praktol, Cardiol, Pralon, Cordialina, Eraldina, Teranol) selektivni je beta blokator koji je korišten u lečenju srčanih aritmija. Praktolol nije više u upotrebi jer je veoma toksičan uprkos toga što je hemijski veoma sličan sa propanololom.[6]

Nuspojave[uredi - уреди | uredi kôd]

Nuspojave ovog leka su tipične za beta blokatore: bronhokonstrikcija, zatajenje srca, zamor, depresija i hipoglikemija.[7]

Zabrana[uredi - уреди | uredi kôd]

Praktolol je zabranjen u Indiji.[8]

Reference[uredi - уреди | uredi kôd]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. British Medical Journal, March 15, 1975
  7. Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. (2007). Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-06911-5. 
  8. „Drugs banned in India”. Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India. Arhivirano iz originala 2015-02-21. https://web.archive.org/web/20150221053621/http://cdsco.nic.in/html/drugsbanned.html. Pristupljeno 17. 9. 2013. 

Литература[uredi - уреди | uredi kôd]

  • Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. (2007). Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-06911-5. 

Spoljašnje veze[uredi - уреди | uredi kôd]

Star of life.svg Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).