Piperoksan
 | |||
| (IUPAC) ime | |||
|---|---|---|---|
| 1-(2,3-dihidro-1,4-benzodioksin-2-ilmetil)piperidin | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 59-39-2 135-87-5 (hidrohlorid) | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 6040 | ||
| ChemSpider[3] | 5817 | ||
| UNII | 9ZCS27634Y  | ||
| ChEMBL[4] | CHEMBL31836 | ||
| Hemijski podaci | |||
| Formula | C14H19NO2 | ||
| Mol. masa | 233,31 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | Nije kontrolisan | ||
| Način primene | Oralno | ||
Piperoksan (benodain) je lek koji je bio privi otkriveni antihistaminik.[5][6] Ovo jedinjenje je izvedeno iz benzodioksana tokom ranih 1930-ih.[5][6] Inicijalno je ispitivano kao blokator α-adrenergičkog receptora. Kasnije je pokazano da ono takođe deluje kao antagonist histaminom indukovanog bronhospazma kod morskih prasića.[5][6][7] Bovet je nagrađen Nobelovom nagradom za fiziologiju ili medicinu 1957. za njegov doprinos.[8] Jedan od njegovih studenata je objavio prvu SAR studiju antihistamina 1939. godine.[5]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- 1 2 3 4 Scriabine, Alexander; Landau, Ralph; Achilladelis, Basil (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. ISBN 0-941901-21-1.
- 1 2 3 Williams, David H.; Lemke, Thomas L.; Foye, William O. (2008). Foye's principles of medicinal chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-6879-9.
- ↑ Fourneau, Ernest; Bovet, Daniel (1933). „Recherches sur l'action sympathicolytique d'un nouveau dérivé du dioxane”. Archives Internationales de Pharmacodynamie et de Thérapie 46: 178-91. ISSN 0003-9780.
- ↑ „Daniel Bovet - Biography”.
- Williams, David H.; Lemke, Thomas L.; Foye, William O. (2008). Foye's principles of medicinal chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-6879-9.
- Scriabine, Alexander; Landau, Ralph; Achilladelis, Basil (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. ISBN 0-941901-21-1.
- Williams, David H.; Lemke, Thomas L.; Foye, William O. (2008). Foye's principles of medicinal chemistry. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-6879-9.
- Scriabine, Alexander; Landau, Ralph; Achilladelis, Basil (1999). Pharmaceutical innovation: revolutionizing human health. Philadelphia: Chemical Heritage Press. ISBN 0-941901-21-1.
