Konesin

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Konesin
Conessine.png
Drugi nazivi N,N-Dimetil-kon-5-enin-3-amin
Identifikacija
CAS registarski broj 546-06-5 YesY
PubChem[1][2] 2860
MeSH Conessine
ChEMBL[3] CHEMBL191703 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C24H40N2
Molarna masa 356,5878

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Konesin je steroidni alkaloid prisutan u brojnim biljnim vrstama iz Apocynaceae familije, uključujući Holarrhena floribunda,[4] Holarrhena antidysenterica[5] i Funtumia elastica,[6] neke od kojih se koriste u tradicionalnom travarstvu kao tretman za amebnu dizenteriju.[7] On deljuje kao histaminski antagonist, koji je selektivan za H3 receptor.[8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. Duez P, Chamart S, Lejoly J, Hanocq M, Zeba B, Sawadogo M, Guissou P, Molle L. Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso. Annales Pharmaceutiques Francaises (French). 1987;45(4):307-13. PMID 3445993
  5. Kumar N, Singh B, Bhandari P, Gupta AP, Kaul VK. Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL. Chemical and Pharmaceutical Bulletin (Tokyo). 2007 Jun;55(6):912-4. PMID 17541193
  6. Zirihi GN, Grellier P, Guédé-Guina F, Bodo B, Mambu L. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorganic and Medicinal Chemistry Letters. 2005 May 16;15(10):2637-40. PMID 15863333
  7. Garg S, Bhutani KK. Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation. Phytochemical Analysis. 2008 Jul;19(4):323-8. PMID 18197597
  8. Santora VJ, Covel JA, Hayashi R, Hofilena BJ, Ibarra JB, Pulley MD, Weinhouse MI, Sengupta D, Duffield JJ, Semple G, Webb RR, Sage C, Ren A, Pereira G, Knudsen J, Edwards JE, Suarez M, Frazer J, Thomsen W, Hauser E, Whelan K, Grottick AJ. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorganic and Medicinal Chemistry Letters. 2008 Feb 15;18(4):1490-4. PMID 18194865

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