Amodiakvin

Amodiakvin
(IUPAC) ime
	4-[(7-hlorohinolin-4-il)amino]-2-[(dietilamino)metil]fenol
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	86-42-0
ATC kod	P01BA06
PubChem	2165
DrugBank	DB00613
ChemSpider	2080
UNII	220236ED28
KEGG	D02922
ChEBI	CHEBI:2674
ChEMBL	CHEMBL682
Hemijski podaci
Formula	C20H22ClN3O
Mol. masa	355,861 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) ; Key: OVCDSSHSILBFBN-UHFFFAOYSA-N
Farmakokinetički podaci
Poluvreme eliminacije	5.2 ± 1.7 (opseg 0.4 to 5.5) minuta
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Amodiakvin (Camoquin, Flavoquine) je 4-aminohinolinsko jedinjenje koje je srodno sa hlorohinom. Koristi se kao antimalarijski i antiinflamatorni agens.

Amodiakvin je efektivniji od hlorohina u tretiranju infekcija CRPF (hlorohin-rezistantne Plasmodium falciparum) malarije i može da pruži veću zaštitu od hlorohina kad se koristi u obliku nedeljnih profilaksi. Amodiakvin, poput hlorohina, je generalno dobro tolerisan. Mada je licenciran ovaj lek nije u prodaji u Sjedinjenim Državama, ali je široko dostupan u Africi. Njegova upotreba je stoga verovatno praktičnija za dugotrajne posetioce i osobe koje borave u Africi.^[6]

Amodiakvin je inhibitor histaminske N-metiltransferaze.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ CDC recommendations for travel to areas with malaria

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] CDC recommendations for travel to areas with malaria

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