Jodofenpropit

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Jodofenpropit
Iodophenpropit.png
IUPAC ime
Drugi nazivi 1-[3-(3H-imidazol-4-il)propiltio]-N'-[2-(4-jodofenil)etil]formamidin
Identifikacija
CAS registarski broj 143407-29-8 YesY
PubChem[1][2] 3035746
MeSH Iodophenpropit
ChEMBL[3] CHEMBL498770 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C15H19IN4S
Molarna masa 414,30763

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Jodofenpropit je histaminski antagonist koji se selektivno vezuje za histaminski H3 receptor. Njegov 125I radioobeležen oblik se koristi za mapiranje distribucije H3 receptora u telu.[4][5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994). "Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain". British Journal of Pharmacology 113 (2): 355–62. PMC 1510107. PMID 7834183. 
  5. Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). "Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit". Naunyn-Schmiedeberg's archives of pharmacology 362 (1): 60–7. PMID 10935534. doi:10.1007/s002100000227. 

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