Hlorciklizin

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Hlorciklizin
(IUPAC) ime
1-[(4-hlorofenil)(fenil)metil]-4-metilpiperazin
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
MedlinePlus a682619
Identifikatori
CAS broj 82-93-9
ATC kod R06AE04
PubChem[1][2] 2710
ChemSpider[3] 2609
UNII M26C4IP44P YesY
ChEMBL[4] CHEMBL22150 YesY
Hemijski podaci
Formula C18H21ClN2 
Mol. masa 300,826 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Prescription only
Način primene Oralno

Hlorciklizin (Diparalen, Mantadil, Pruresidin, Trihistan) je prva generacija antihistamina iz fenilpiperazinske klase.[5][6][7] On se prvenstveno koristi za tretiranje simptoma alergije kao što su rinitis, urtikarija, i pruritus, a može se koristiti i kao antiemetik.[5][6][7] Osim njegovog antihistaminskog dejstva, hlorciklizin takođe ima antiholinergične, antiserotinergične, i lokalne anestetičke osobine.[8][9]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. 5,0 5,1 Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA1228&dq=Chlorcyclizine&pg=PA212#v=onepage&q&f=false. 
  6. 6,0 6,1 Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. http://books.google.com/books?id=DeX7jgInYFMC&lpg=PA417&dq=Chlorcyclizine&pg=PA417#v=onepage&q&f=false. 
  7. 7,0 7,1 Hall, Judith A.; Morton, Ian (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. ISBN 0-7514-0499-3. http://books.google.com/books?id=mqaOMOtk61IC&lpg=PA72&dq=Chlorcyclizine&pg=PA72#v=onepage&q&f=false. 
  8. Dorland Staff (2008). Dorland Dictionnaire Medical Bilingue Francais-anglais / Anglais-francais: + E-book a Telecharger (French Edition). Elsevier (Educa Books). ISBN 2-84299-899-5. http://books.google.com/books?id=tQNqwsnkK-QC&lpg=PA1152&dq=chlorcyclizine%20anticholinergic&lr&as_brr=3&pg=PA1152#v=onepage&q&f=false. 
  9. Rogóz Z, Skuza G, Sowińska H (November 1981). "The effect of the antihistaminic drugs on the central action of 5-hydroxytryptophan in mice". Polish Journal of Pharmacology and Pharmacy 33 (4): 459–65. PMID 6120505. 

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