Hidroksizin

Hidroksizin
(IUPAC) ime
	(±)-2-(24-[(4-hlorofenil)-fenilmetil]piperazin-1-il}etoksi)etanol
Klinički podaci
Robne marke	Vistaril
AHFS/Drugs.com	Monografija
MedlinePlus	a682866
Identifikatori
CAS broj	68-88-2
ATC kod	N05BB01
PubChem	3658
DrugBank	DB00557
ChemSpider	3531
UNII	30S50YM8OG
KEGG	D08054
ChEBI	CHEBI:5818
ChEMBL	CHEMBL896
Hemijski podaci
Formula	C21H27ClN2O2
Mol. masa	374,904 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2 ; Key: ZQDWXGKKHFNSQK-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	visoka
Vezivanje za proteine plazme	93%
Metabolizam	Renalno
Poluvreme eliminacije	20,0 ± 4,1 sata
Izlučivanje	Urin, izmet
Farmakoinformacioni podaci
Trudnoća	A(AU) C(US)
Pravni status	℞ Prescription only
Način primene	Oralno, IM

Hidroksizin (Vistaril, Ataraks) pripada prvoj generaciji antihistamina difenilmetanske i piperazinske klase. On je prvi put sintetisan 1956. i u prodaji je bio od strane kompanije Pfizer u SAD-u iste godine.^[7] On je još uvek u širokoj upotrebi.

Hemija[uredi | uredi kod]

Hidroksizin se može sintetisati alkilacijom 1-(4-hlorobenzohidril)piperazina sa 2-(2-hidroksietoksi)etilhloridom:^[8]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Simons FE, Simons KJ, Frith EM (January 1984). „The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine”. The Journal of Allergy and Clinical Immunology 73 (1 Pt 1): 69–75. PMID 6141198.
↑ Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6.
↑ H. Morren, U.S. Patent 2.899.436 (1959); H. Morren, DE 1049383 (1954); H. Morren, DE 1061786 (1954); H. Morren, DE 1068262 (1954); H. Morren, DE 1072624 (1954); H. Morren, DE 1075116 (1954).

Literatura[uredi | uredi kod]

Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6.

Hutcheon, D. E.; D.L. Morris, A. Scriabine (December 1956). „Cardiovascular action of hydroxyzine (Atarax)”. J Pharmacol Exp Ther. 118 (4): 451–460. PMID 13385806.
Dolan, C. M. (June 1958). „MANAGEMENT OF EMOTIONAL DISTURBANCES—Use of Hydroxyzine (Atarax®) in General Practice”. Calif Med. 88 (6): 443–444. PMC 1512309. PMID 13536863.
Pfizer Labs, Division of Pfizer Inc, NY, NY 10017 (2004) (pdf). Vistaril (hydroxyzine pamoate) Capsules and Oral Suspension. United States Food and Drug Administration.
Anderson, Philip O.; James E. Knoben, William G. Troutman (2002). Handbook of Clinical Drug Data. McGraw-Hill Medical. ISBN 0-07-136362-9.
de Brabander, A.; W. Deberdt (1990). „Effect of Hydroxyzine on Attention and Memory”. Human Psychopharmacology (John Wiley & Sons) 5 (4): 357–362. DOI:10.1002/hup.470050408. Pristupljeno 2007-03-09. ^{[mrtav link]}
Clark, B. G.; M. Araki, H. W. Brown (1982). „Hydroxyzine-Associated Tardive Dyskinesia”. Ann Neurol. 11 (4): 435. DOI:10.1002/ana.410110423. PMID 7103423.
Porsolt, R. D.; P. Martin, A. Lenegre, S. Frornage, and C.E. Giurgea (1989). „Prevention of "Learned Helplessness" in the Rat by Hydroxyzine”. Drug Dev. Res. 17 (3): 227–236. DOI:10.1002/ddr.430170306. Pristupljeno 2007-03-10. ^{[mrtav link]}
Alford, C.; N. Rombautt, J. Jones, S. Foley, C. Idzikowskit and I. Hindmarch (1992). „Acute Effects of Hydroxyzine on Nocturnal Sleep and Sleep Tendency the Following Day: a C-EEG Study”. Human Psychopharmacology 7 (1): 25–35. DOI:10.1002/hup.470070104. Pristupljeno 2007-03-10. ^{[mrtav link]}
RxList, et al. (2004). „Atarax Indications, Dosage, Storage, Stability”. RxList - The internet drug index. Arhivirano iz originala na datum 2008-09-06. Pristupljeno 9. 3. 2007.
Medscape (2004). „Vistaril Oral: Monograph - Hydroxyzine Hydrochloride, Hydroxyzine Pamoate”. medscape.com. Pristupljeno 9. 3. 2007.

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

U.S. National Library of Medicine: Drug Information Portal - Hydroxyzine

Šablon:Sedativi

Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid6141198-6] Simons FE, Simons KJ, Frith EM (January 1984). „The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine”. The Journal of Allergy and Clinical Immunology 73 (1 Pt 1): 69–75. PMID 6141198.

[isbn0-19-536874-6-7] Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6.

[8] H. Morren, U.S. Patent 2.899.436 (1959); H. Morren, DE 1049383 (1954); H. Morren, DE 1061786 (1954); H. Morren, DE 1068262 (1954); H. Morren, DE 1072624 (1954); H. Morren, DE 1075116 (1954).

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Hidroksizin

Sadržaj

Hemija[uredi | uredi kod]

Reference[uredi | uredi kod]

Literatura[uredi | uredi kod]

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