L-765,314

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L-765,314
(IUPAC) ime
benzil (2S)-4-(4-amino-6,7-dimetoksihinazolin-2-il)-2-(tert-butilkarbamoil)piperazin-1-karboksilat
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 6603904
ChEMBL[3] CHEMBL19476
Hemijski podaci
Formula C27H34N6O5 
Mol. masa 522,595 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

L-765,314 je lek koji deluje kao potentan i selektivan antagonist za alfa-1 adrenergički receptor α1B.[4] On se uglavnom koristi za istraživanje uloge α1B receptora u regulaciji krvnog pritiska,[5][6] mada se smatra da α1B receptor isto tako ima važnu ulogu u mozgu.[7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. Patane MA, Scott AL, Broten TP, Chang RS, Ransom RW, DiSalvo J, Forray C, Bock MG (April 1998). "4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist ". Journal of Medicinal Chemistry 41 (8): 1205–8. PMID 9548811. doi:10.1021/jm980053f. 
  5. Yang XP, Chiba S (August 2002). "Effects of L-765,314, a selective and potent alpha 1B-adrenoceptor antagonist, on periarterial nerve electrical stimulation-induced double-peaked constrictor responses in isolated dog splenic arteries". Japanese Journal of Pharmacology 89 (4): 429–32. PMID 12233824. doi:10.1254/jjp.89.429. 
  6. Görnemann T, Villalón CM, Centurión D, Pertz HH (June 2009). "Phenylephrine contracts porcine pulmonary veins via alpha(1B)-, alpha(1D)-, and alpha(2)-adrenoceptors". European Journal of Pharmacology 613 (1–3): 86–92. PMID 19376108. doi:10.1016/j.ejphar.2009.04.011. 
  7. Hillman KL, Doze VA, Porter JE (June 2007). "Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus". The Journal of Pharmacology and Experimental Therapeutics 321 (3): 1062–8. PMID 17337632. doi:10.1124/jpet.106.119297. 

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