Tizanidin

Tizanidin
(IUPAC) ime
	5-hloro-N-(4,5-dihdro-1H-imidazol-2-il)benzo[c][1,2,5]tiadiazol-4-amin
Klinički podaci
Robne marke	Zanafleks
AHFS/Drugs.com	Monografija
MedlinePlus	a601121
Identifikatori
CAS broj	51322-75-9
ATC kod	M03BX02
PubChem	5487
DrugBank	DB00697
ChemSpider	5287
UNII	6AI06C00GW
KEGG	D08611
ChEMBL	CHEMBL1079
Hemijski podaci
Formula	C9H8ClN5S
Mol. masa	253,712 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13) ; Key: XFYDIVBRZNQMJC-UHFFFAOYSA-N
Sinonimi	4-hloro-N-(4,5-dihidro-1H-imidazol-2-il)-8-tia-7,9-diazabiciklo[4.3.0]nona-2,4,6,9-tetraen-5-amin
Farmakokinetički podaci
Vezivanje za proteine plazme	30%
Metabolizam	CYP1A2
Poluvreme eliminacije	2,54 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞-only (SAD)
Način primene	Oralno, intranazalno, injekcija

Tizanidin (Zanafleks, Sirdalud) je lek koji se koristi kao mišićni relaksant. On je centralno delujući α₂ adrenergički agonist. On se koristi za tretiranje spazama, grčeva, i stegnutosti mišića uzrokovane medicinskim problemima poput multiple skleroze, spastičke diplegije, bola u leđima, ili pojedinih drugih povreda kičme ili centralnog nervnog sistema. On može da pomogle u lečenju migrene i glavobolje, da poboljša san, i da služi kao antikonvulsant, mada nije odobren za te indikacije. On se isto tako propisuje za neke od simptoma fibromialgije.^[6]

Utvrđeno je da je tizanidin efektivan poput drugih antizpazmodka i da je bolje tolerisan od baklofena i diazepama.^[7] Tizanidin može da uzrokuje hipotenziju, tako da se oprezom treba koristi kod osoba sa istorijom ortostatičke hipotenzije. Ovaj lek može da bude veoma jak, čak i u dozama od 2 mg.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Zanaflex for Fibromyalgia
↑ Kamen, L.; Henney, HR.; Runyan, JD. (Feb 2008). „A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.”. Curr Med Res Opin 24 (2): 425–39. DOI:10.1185/030079908X261113. PMID 18167175.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Zanaflex for Fibromyalgia

[Kamen-2008-7] Kamen, L.; Henney, HR.; Runyan, JD. (Feb 2008). „A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.”. Curr Med Res Opin 24 (2): 425–39. DOI:10.1185/030079908X261113. PMID 18167175.

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