Natrijum tiopental

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Natrijum tiopental
(IUPAC) ime
5-etil-5-(pentan-2-il)-2-fulfaniliden-1,3-diazinan-4,6-dion
Klinički podaci
Robne marke Farmotal, Intraval, Nesdonal, Thiothal
AHFS/Drugs.com thiopental.html Monografija
Identifikatori
CAS broj 76-75-5
ATC kod N01AF03 , N05CA19
PubChem[1][2] 3000715
DrugBank DB00599
ChemSpider[3] 2272258
KEGG[4] C07521 YesY
ChEMBL[5] CHEMBL102166 YesY
Hemijski podaci
Formula C11H18N2O2S 
Mol. masa 242.338
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Poluvreme eliminacije 3-8 sati
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Intravenozno

Natrijum tiopental je barbiturat koji se intravenozno administrira radi indukcije opšte anestezije ili ostvarivanja kompletne anestezije tokom kratkog vremenskog perioda. On se takođe korisiti pri hipnozi, i kontroli konvulzivnih stanja. On je primenjivan kod neurohirurških pacijenata s ciljem snižavanja povišenog intrakranijalnog pritiska. On ne proizvodi pobuđenost ali ima slaba analgetička i mišićno relaksantna svojstva.[6][7][8][9][10][11][12]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Martindale, The Extra Pharmacopoeia, 30th ed, p920
  7. Morgan DJ, Blackman GL, Paull JD, Wolf LJ: Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section. Anesthesiology. 1981 Jun;54(6):474-80. PMID 7235275
  8. Perez-Barcena J, Barcelo B, Homar J, Abadal JM, Molina FJ, de la Pena A, Sahuquillo J, Ibanez J: [Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients] Neurocirugia (Astur). 2005 Feb;16(1):5-12; discussion 12-3. PMID 15756405
  9. WINTERS WD, SPECTOR E, WALLACH DP, SHIDEMAN FE: Metabolism of thiopental-S35 and thiopental-2-C14 by a rat liver mince and identification of pentobarbital as a major metabolite. J Pharmacol Exp Ther. 1955 Jul;114(3):343-57. PMID 13243246
  10. Bory C, Chantin C, Boulieu R, Cotte J, Berthier JC, Fraisse D, Bobenrieth MJ: [Use of thiopental in man. Determination of this drug and its metabolites in plasma and urine by liquid phase chromatography and mass spectrometry] C R Acad Sci III. 1986;303(1):7-12. PMID 3093002
  11. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035–41. PMID 21059682. 
  12. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets" 36 (Database issue). pp. D901–6. PMID 18048412. 

Spoljašnje veze[uredi - уреди | uredi izvor]

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