Bromizoval

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Bromizoval
Skeletal formula of bromisoval
IUPAC ime
Identifikacija
CAS registarski broj 496-67-3 YesY, 27109-49-5 R YesY
PubChem[1][2] 2447
146955 R
735997 S
ChemSpider[3] 2353 YesY, 129594 R YesY, 643139 S YesY
UNII 469GW8R486 YesY
EINECS broj 207-825-7
KEGG[4] D01391
MeSH Bromisovalum
ChEMBL[5] CHEMBL1515611 YesY
ATC code N05CM03
Jmol-3D slike Slika 1
Slika 2
Svojstva
Molekulska formula C6H11BrN2O2
Molarna masa 223.07 g mol−1
log P 1,057
pKa 10,536
Baznost (pKb) 3;461
Farmakologija
Načini upotrebe Oralno
Srodna jedinjenja
Srodna ureje Karbromal
Srodna jedinjenja



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Bromizoval (bromvalerilureja) je hipnotik i sedativ koji je bio otkriven 1907.[6] One je u prodaji na slobodno u Aziji pod mnoštvom naziva (kao što je Brovarin[7]). On se obično koristi u kombinaciji sa nesteroidnim antiinflamatornim lekovima.

Hronična upotreba bromizovala je vezana za trovanje bromom.[8][9][10][11]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. "Alpha-halogen-isovaleryl-urea and process of making the same" US patent 914518, issued 09. 03. 1909., assigned to Knoll 
  7. "Bromisoval". International. Drugs.com. http://www.drugs.com/international/bromisoval.html. 
  8. Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001). "A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia" (PDF). Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics (in Japanese) 38 (5): 700–703. ISSN 0300-9173. PMID 11605223. doi:10.3143/geriatrics.38.700. 
  9. Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998). "Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse" (PDF). Internal Medicine (Tokyo, Japan) 37 (9): 788–791. PMID 9804091. doi:10.2169/internalmedicine.37.788. 
  10. Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005). "Pseudohyperchloraemia due to bromvalerylurea abuse". Nephrology Dialysis Transplantation 20 (8): 1767–1768. PMID 15972320. doi:10.1093/ndt/gfh945. 
  11. Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997). "Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning" (PDF). Internal Medicine (Tokyo, Japan) 36 (10): 742–746. PMID 9372340. doi:10.2169/internalmedicine.36.742. 

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