Trazodon

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Trazodon
(IUPAC) ime
23-[4-(3-hlorofenil)piperazin-1-il]propil}[1,2,4]triazolo[4,3-a]piridin-3(2H)-on
Klinički podaci
AHFS/Drugs.com Monografija
MedlinePlus a681038
Identifikatori
CAS broj 19794-93-5
ATC kod N06AX05
PubChem[1][2] 5533
DrugBank DB00656
ChemSpider[3] 5332
UNII YBK48BXK30 YesY
KEGG[4] D08626 YesY
ChEBI CHEBI:9654 YesY
ChEMBL[5] CHEMBL621 YesY
Hemijski podaci
Formula C19H22ClN5O 
Mol. masa 371,864 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost visoka
Metabolizam Hepatički
Poluvreme eliminacije 3-6 sata
Izlučivanje 20% izmet,
80% urin
Farmakoinformacioni podaci
Trudnoća C(US)
Pravni status Prescription only
Način primene Oralno

Trazodon (Desorel, Oleptro, Benefikat, Depraks, Desirel, Molipaksin, Tombran, Trazorel, Trialodin, Tritiko, i Mesirel) je antidepresiv iz klase serotoninskih antagonista i inhibitora preuzimanja. On je fenilpiperazinsko jedinjenje. Trazodon je isto tako anksiolitik i hipnotik.[6] Trazodon ima znatno manje izražene nuspojave koje su karakteristične za triciklične antidepresive.

Sinteza[uredi - уреди | uredi kôd]

Jedan od sintetičkih puteva je:[7][8]

Trazodone synthesis.png

Reference[uredi - уреди | uredi kôd]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. http://www.sciencedirect.com/science/article/pii/S1359644610007737.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. http://www.jcheminf.com/content/2/1/3.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-0061%28200004%2917:1%3C48::AID-YEA2%3E3.0.CO;2-H/full. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Haria M, Fitton A, McTavish D (April 1994). „Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders”. Drugs Aging 4 (4): 331–55. DOI:10.2165/00002512-199404040-00006. PMID 8019056. 
  7. Palazzo, G.; Silvestrini, B.; 1968, U.S. Patent 3,381,009.
  8. B. Silvestrini, G. Palazzo, DE 164594 

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