Perospiron

Perospiron
(IUPAC) ime
	(3aR,7aS)-24-[4-(1,2-benzizotiazol-3-il)piperazin-1-il]butil}heksahidro-1H-izoindol-1,3(2H)-dion
Klinički podaci
Robne marke	Lulan
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	150915-41-6
ATC kod	nije dodeljen
PubChem	115368
ChemSpider	16737064
UNII	N303OK87DT
Hemijski podaci
Formula	C23H30N4O2S
Mol. masa	426,57 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C24H32N4O2S/c29-23-20-9-3-4-10-21(20)24(30)28(23)12-6-5-11-26-13-15-27(16-14-26)22-19-8-2-1-7-18(19)17-31-25-22/h1-2,7-8,20-21H,3-6,9-17H2/t20-,21+ ; Key: GTAIPSDXDDTGBZ-OYRHEFFESA-N
Farmakokinetički podaci
Poluvreme eliminacije	2-2,5 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralnot

Perospiron (Lulan) je atipični antipsihotik iz azapironske hemijske klase.^[4] Njega je razvila japanska kompanija Dajnipon sumitomo farma 2001 za lečenje šizofrenije i akutne bipolarne manije.^[5]^[6] Perospiron deluje kao parcijalni agonist 5-HT_1A receptora, inverzni agonist 5-HT_2A receptora i antagonist D₂, D₄ i α₁-adrenergičkog receptora.^[7]^[8]^[9]^[10]

Reference[uredi - уреди | uredi izvor]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3. edit
↑ Onrust SV, McClellan K (2001). "Perospirone". CNS Drugs 15 (4): 329–37; discussion 338. PMID 11463136. doi:10.2165/00023210-200115040-00006.
↑ de Paulis T (January 2002). "Perospirone (Sumitomo Pharmaceuticals)". Current Opinion in Investigational Drugs (London, England : 2000) 3 (1): 121–9. PMID 12054062.
↑ "Sumitomo Pharmaceuticals 2001 | News Release | Dainippon Sumitomo Pharma". http://www.ds-pharma.co.jp/english/news/sumitomo_2001/no_002.html.
↑ Hirose A, Kato T, Ohno Y et al. (July 1990). "Pharmacological actions of SM-9018, a new neuroleptic drug with both potent 5-hydroxytryptamine2 and dopamine2 antagonistic actions". Japanese Journal of Pharmacology 53 (3): 321–9. PMID 1975278. doi:10.1254/jjp.53.321.
↑ Kato T, Hirose A, Ohno Y, Shimizu H, Tanaka H, Nakamura M (December 1990). "Binding profile of SM-9018, a novel antipsychotic candidate". Japanese Journal of Pharmacology 54 (4): 478–81. PMID 1982326. doi:10.1254/jjp.54.478.
↑ Odagaki Y, Toyoshima R (2007). "5-HT1A receptor agonist properties of antipsychotics determined by [35S]GTPgammaS binding in rat hippocampal membranes". Clinical and Experimental Pharmacology & Physiology 34 (5–6): 462–6. PMID 17439416. doi:10.1111/j.1440-1681.2007.04595.x.
↑ Seeman P, Tallerico T (March 1998). "Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors". Molecular Psychiatry 3 (2): 123–34. PMID 9577836. doi:10.1038/sj.mp.4000336.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3. edit

[pmid11463136-4] Onrust SV, McClellan K (2001). "Perospirone". CNS Drugs 15 (4): 329–37; discussion 338. PMID 11463136. doi:10.2165/00023210-200115040-00006.

[pmid12054062-5] Paulis T (January 2002). "Perospirone (Sumitomo Pharmaceuticals)". Current Opinion in Investigational Drugs (London, England : 2000) 3 (1): 121–9. PMID 12054062.

[urlSumitomo_Pharmaceuticals_2001_|_News_Release_|_Dainippon_Sumitomo_Pharma-6] "Sumitomo Pharmaceuticals 2001 | News Release | Dainippon Sumitomo Pharma". http://www.ds-pharma.co.jp/english/news/sumitomo_2001/no_002.html.

[pmid1975278-7] Hirose A, Kato T, Ohno Y et al. (July 1990). "Pharmacological actions of SM-9018, a new neuroleptic drug with both potent 5-hydroxytryptamine2 and dopamine2 antagonistic actions". Japanese Journal of Pharmacology 53 (3): 321–9. PMID 1975278. doi:10.1254/jjp.53.321.

[pmid1982326-8] Kato T, Hirose A, Ohno Y, Shimizu H, Tanaka H, Nakamura M (December 1990). "Binding profile of SM-9018, a novel antipsychotic candidate". Japanese Journal of Pharmacology 54 (4): 478–81. PMID 1982326. doi:10.1254/jjp.54.478.

[pmid17439416-9] Odagaki Y, Toyoshima R (2007). "5-HT1A receptor agonist properties of antipsychotics determined by [35S]GTPgammaS binding in rat hippocampal membranes". Clinical and Experimental Pharmacology & Physiology 34 (5–6): 462–6. PMID 17439416. doi:10.1111/j.1440-1681.2007.04595.x.

[pmid9577836-10] Seeman P, Tallerico T (March 1998). "Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors". Molecular Psychiatry 3 (2): 123–34. PMID 9577836. doi:10.1038/sj.mp.4000336.

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Perospiron

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