Ro10-5824

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Ro10-5824
(IUPAC) ime
2-metil-5-[(4-fenil-3,6-dihidro-2H-piridin-1-il)metil]pirimidin-4-amin
Klinički podaci
Identifikatori
CAS broj 189744-46-5
ATC kod nije dodeljen
PubChem[1][2] 16759175
Hemijski podaci
Formula C17H20N4 
Mol. masa 280,367 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Ro10-5824 je lek koji deluje kao dopaminski agonist. On je selektivni parcijalni agonist D4 podtipa. Ro10-5824 deluje kao kognitivni pojačivač u životinjskim studijama.[3][4]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Powell SB, Paulus MP, Hartman DS, Godel T, Geyer MA (March 2003). "RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice". Neuropharmacology 44 (4): 473–81. PMID 12646284. doi:10.1016/S0028-3908(02)00412-4. 
  4. Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D (May 2008). "Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells". The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 11 (3): 293–307. PMID 17897483. doi:10.1017/S1461145707008061. 

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