Rakloprid

Rakloprid
(IUPAC) ime
	3,5-dihlor-N[(2S)-1-etilpirolidin-2-il]metil2-hidroksi-6-metoksibenzamid
Klinički podaci
Identifikatori
CAS broj	84225-95-6
ATC kod	nije dodeljen
PubChem	3033769
ChemSpider	2298373
UNII	430K3SOZ7G
ChEMBL	CHEMBL8809
Hemijski podaci
Formula	C15H20Cl2N2O3
Mol. masa	347,236 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1 ; Key: WAOQONBSWFLFPE-VIFPVBQESA-N
Farmakokinetički podaci
Poluvreme eliminacije	30 min
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Rakloprid je sintetičko jedinjenje koje deluje kao antagonist na D2 dopaminskom receptoru.^[5] On se može radio obeležiti radioizotopom ugljenik-11 i koristiti u pozitronskom emisiono tomografskom (PET) skeniranju za utvrđivanje stepena dopaminskog vezivanja za D₂ dopaminski receptor. Na primer, jedna studija je utvrdila da postoji umanjeno vezivanje kod osoba sa emocionom otuđenošću.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ C. Kohler, H. Hall, S. O. Ogren, L. Gawell (July 1985). „Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain”. Biochemical Pharmacology 34 (13): 2251–2259. DOI:10.1016/0006-2952(85)90778-6. PMID 4015674.
↑ Lars Farde, J. Petter Gustavsson, Erik Jönsson (February 1997). „D2 dopamine receptors and personality traits”. Nature 385 (6617): 590. DOI:10.1038/385590a0. PMID 9024656.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

ChemSpider

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] C. Kohler, H. Hall, S. O. Ogren, L. Gawell (July 1985). „Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain”. Biochemical Pharmacology 34 (13): 2251–2259. DOI:10.1016/0006-2952(85)90778-6. PMID 4015674.

[6] Lars Farde, J. Petter Gustavsson, Erik Jönsson (February 1997). „D2 dopamine receptors and personality traits”. Nature 385 (6617): 590. DOI:10.1038/385590a0. PMID 9024656.

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