CY-208243

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(Preusmjereno sa CY-208,243)
CY-208243
(IUPAC) ime
4,6,6a,7,8,12b-heksahidro-7-metilindolo(4,3-ab)-fenantridin
Klinički podaci
Identifikatori
CAS broj 100999-26-6
ATC kod nije dodeljen
PubChem[1][2] 58144
Hemijski podaci
Formula C19H18N2 
Mol. masa 274,359 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

CY-208,243 je lek koji deluje kao selektivni dopaminski agonist za D1 podtipe. Za razliku od većene D1-selektivnih agonista, on je pokazao efikasnot u životinjskim modelima za Parkinsonovu bolest.[3][4][5][6][7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). "Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors". Progress in Neuro-psychopharmacology & Biological Psychiatry 19 (4): 667–76. PMID 8588064. 
  4. Beninger RJ, Rolfe NG (December 1995). "Dopamine D1-like receptor agonists impair responding for conditioned reward in rats". Behavioural Pharmacology 6 (8): 785–793. PMID 11224381. 
  5. Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). "Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys". Advances in Neurology 69: 239–44. PMID 8615134. 
  6. D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). "Dopamine D1 receptor agonists induce penile erections in rats". European Journal of Pharmacology 460 (1): 71–4. PMID 12535862. doi:10.1016/S0014-2999(02)02881-9. 
  7. Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). "Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243". Behavioural Brain Research 156 (2): 173–9. PMID 15582103. doi:10.1016/j.bbr.2004.05.019. 

Spoljašnje veze[uredi - уреди | uredi izvor]


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