CY-208243

CY-208243
(IUPAC) ime
	4,6,6a,7,8,12b-heksahidro-7-metilindolo(4,3-ab)-fenantridin
Klinički podaci
Identifikatori
CAS broj	100999-26-6
ATC kod	nije dodeljen
PubChem	58144
Hemijski podaci
Formula	C19H18N2
Mol. masa	274,359 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H18N2/c1-21-11-12-5-2-3-6-14(12)19-15-7-4-8-16-18(15)13(10-20-16)9-17(19)21/h2-8,10,17,19-20H,9,11H2,1H3 ; Key: WRNKIDLXXXIELU-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

CY-208,243 je lek koji deluje kao selektivni dopaminski agonist za D₁ podtipe. Za razliku od većene D₁-selektivnih agonista, on je pokazao efikasnot u životinjskim modelima za Parkinsonovu bolest.^[3]^[4]^[5]^[6]^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). „Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors”. Progress in Neuro-psychopharmacology & Biological Psychiatry 19 (4): 667–76. PMID 8588064.
↑ Beninger RJ, Rolfe NG (December 1995). „Dopamine D1-like receptor agonists impair responding for conditioned reward in rats”. Behavioural Pharmacology 6 (8): 785–793. PMID 11224381.
↑ Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). „Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys”. Advances in Neurology 69: 239–44. PMID 8615134.
↑ D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). „Dopamine D1 receptor agonists induce penile erections in rats”. European Journal of Pharmacology 460 (1): 71–4. DOI:10.1016/S0014-2999(02)02881-9. PMID 12535862.
↑ Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). „Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243”. Behavioural Brain Research 156 (2): 173–9. DOI:10.1016/j.bbr.2004.05.019. PMID 15582103.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid8588064-3] Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). „Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors”. Progress in Neuro-psychopharmacology & Biological Psychiatry 19 (4): 667–76. PMID 8588064.

[pmid11224381-4] Beninger RJ, Rolfe NG (December 1995). „Dopamine D1-like receptor agonists impair responding for conditioned reward in rats”. Behavioural Pharmacology 6 (8): 785–793. PMID 11224381.

[pmid8615134-5] Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). „Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys”. Advances in Neurology 69: 239–44. PMID 8615134.

[pmid12535862-6] D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). „Dopamine D1 receptor agonists induce penile erections in rats”. European Journal of Pharmacology 460 (1): 71–4. DOI:10.1016/S0014-2999(02)02881-9. PMID 12535862.

[pmid15582103-7] Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). „Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243”. Behavioural Brain Research 156 (2): 173–9. DOI:10.1016/j.bbr.2004.05.019. PMID 15582103.

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