Dinoksilin

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Dinoksilin
(IUPAC) ime
8,9-dihidroksi-1,2,3,11b-tetrahidrochromeno[4,3,2,-de]isoquinoline
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 9819126
Hemijski podaci
Formula C15H13NO3 
Mol. masa 255,268
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Dinoksilin je sintetičko jedinjenje koje je razvijeno za primenu u naučnim istraživanjima. Dinoksilin deluje kao potentan pun agonist na svih pet podtipova dopaminskog receptora.[3][4][5]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE (March 2004). "8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms". Bioorganic & Medicinal Chemistry 12 (6): 1403–12. PMID 15018913. doi:10.1016/j.bmc.2004.01.008. 
  4. Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). "Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists". Molecular Pharmacology 68 (4): 1039–48. PMID 15985612. doi:10.1124/mol.105.012153. 
  5. Zhang J, Xiong B, Zhen X, Zhang A (March 2009). "Dopamine D1 receptor ligands: where are we now and where are we going". Medicinal Research Reviews 29 (2): 272–94. PMID 18642350. doi:10.1002/med.20130. 

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