BP-897

BP-897
(IUPAC) ime
	N-[4-[4-(2-metoksifenil)piperazin-1-il]butil]naftalen-2-karboksamid
Klinički podaci
Identifikatori
CAS broj	314776-92-6
ATC kod	nije dodeljen
PubChem	3038495
ChEMBL	CHEMBL25236
Hemijski podaci
Formula	C26H31N3O2
Mol. masa	417,542 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C26H31N3O2/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30) ; Key: MNHDKMDLOJSCGN-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

BP-897 je lek koji se koristi u naučnim istraživanjima. On deluje kao umereno selektivni parcijalni agonist dopaminski D₃ receptora.^[4] On je uglavnom korišćen za studiranje tretmana za kokainsku adikciju.^[5]^[6]^[7]^[8]^[9]^[10]^[11]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P (July 1999). „Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist”. Nature 400 (6742): 371–5. DOI:10.1038/22560. PMID 10432116.
↑ Beardsley PM, Sokoloff P, Balster RL, Schwartz JC (February 2001). „The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered”. Behavioural Pharmacology 12 (1): 1–11. PMID 11270507.
↑ Garcia-Ladona FJ, Cox BF (2003). „BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction”. CNS Drug Reviews 9 (2): 141–58. PMID 12847556.
↑ Duarte C, Lefebvre C, Chaperon F, Hamon M, Thiébot MH (November 2003). „Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats”. Neuropsychopharmacology 28 (11): 1903–15. DOI:10.1038/sj.npp.1300276. PMID 12915863.
↑ Hsu A, Togasaki DM, Bezard E, Sokoloff P, Langston JW, Di Monte DA, Quik M (November 2004). „Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys”. The Journal of Pharmacology and Experimental Therapeutics 311 (2): 770–7. DOI:10.1124/jpet.104.071142. PMID 15226382.
↑ Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, Peng XQ, Xi ZX (July 2005). „Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors”. Synapse (New York, N.Y.) 57 (1): 17–28. DOI:10.1002/syn.20152. PMID 15858839.
↑ Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR, Heidbreder C, Gaál J, Gardner EL (March 2008). „The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats”. Psychopharmacology 196 (4): 533–42. DOI:10.1007/s00213-007-0986-6. PMID 17985117.
↑ Hocke C, Prante O, Salama I, Hübner H, Löber S, Kuwert T, Gmeiner P (May 2008). „18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor”. Chemmedchem 3 (5): 788–93. DOI:10.1002/cmdc.200700327. PMID 18306190.

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid10432116-4] Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P (July 1999). „Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist”. Nature 400 (6742): 371–5. DOI:10.1038/22560. PMID 10432116.

[pmid11270507-5] Beardsley PM, Sokoloff P, Balster RL, Schwartz JC (February 2001). „The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered”. Behavioural Pharmacology 12 (1): 1–11. PMID 11270507.

[pmid12847556-6] Garcia-Ladona FJ, Cox BF (2003). „BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction”. CNS Drug Reviews 9 (2): 141–58. PMID 12847556.

[pmid12915863-7] Duarte C, Lefebvre C, Chaperon F, Hamon M, Thiébot MH (November 2003). „Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats”. Neuropsychopharmacology 28 (11): 1903–15. DOI:10.1038/sj.npp.1300276. PMID 12915863.

[pmid15226382-8] Hsu A, Togasaki DM, Bezard E, Sokoloff P, Langston JW, Di Monte DA, Quik M (November 2004). „Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys”. The Journal of Pharmacology and Experimental Therapeutics 311 (2): 770–7. DOI:10.1124/jpet.104.071142. PMID 15226382.

[pmid15858839-9] Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, Peng XQ, Xi ZX (July 2005). „Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors”. Synapse (New York, N.Y.) 57 (1): 17–28. DOI:10.1002/syn.20152. PMID 15858839.

[pmid17985117-10] Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR, Heidbreder C, Gaál J, Gardner EL (March 2008). „The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats”. Psychopharmacology 196 (4): 533–42. DOI:10.1007/s00213-007-0986-6. PMID 17985117.

[pmid18306190-11] Hocke C, Prante O, Salama I, Hübner H, Löber S, Kuwert T, Gmeiner P (May 2008). „18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor”. Chemmedchem 3 (5): 788–93. DOI:10.1002/cmdc.200700327. PMID 18306190.

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BP-897

Reference[uredi | uredi kod]

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