Hinpirol

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Hinpirol
Quinpirole.png
IUPAC ime
Identifikacija
CAS registarski broj 80373-22-4 YesY
PubChem[1][2] 54562
ChEMBL[3] CHEMBL240773 YesY
IUPHAR ligand 2
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C13H21N3
Molarna masa 219.33 g mol−1

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Hinpirol je psihoaktivni lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni agonist D2 i D3 receptora.[4][5][6] Za hinpirol je pokazano da povećava lokomotornu aktivnost kod miševa. U jednoj studiji je nađeno da on indukuje kompulzivno ponašanje koje je simptomatično za opsesivno-kompulzivni poremećaj kod pacova.[7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  4. Eilam D, Szechtman H (February 1989). "Biphasic effect of D-2 agonist quinpirole on locomotion and movements". European Journal of Pharmacology 161 (2–3): 151–7. PMID 2566488. doi:10.1016/0014-2999(89)90837-6. 
  5. Navarro JF, Maldonado E (September 1999). "Behavioral profile of quinpirole in agonistic encounters between male mice". Methods and Findings in Experimental and Clinical Pharmacology 21 (7): 477–80. PMID 10544391. 
  6. Culm KE, Lugo-Escobar N, Hope BT, Hammer RP (October 2004). "Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats". Neuropsychopharmacology 29 (10): 1823–30. PMID 15138441. doi:10.1038/sj.npp.1300483. 
  7. Szechtman Henry, Sulis William, Eilam David (1998). "Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD)". Behavioral Neuroscience 112 (6): 1475–85. PMID 9926830. doi:10.1037/0735-7044.112.6.1475. 

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