SKF-38393

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SKF-38393
(IUPAC) ime
1-fenil-2,3,4,5-tetrahidro-1H-3-benzazepin-7,8-diol
Klinički podaci
Identifikatori
CAS broj 67287-49-4
ATC kod nije dodeljen
PubChem[1][2] 1242
ChemSpider[3] 1205
ChEMBL[4] CHEMBL24077 DaY
Hemijski podaci
Formula C16H17NO2 
Mol. masa 255,31 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

SKF-38393 je sintetičko jedinjenje iz benzazepinske hemijske klase koje deluje kao selektivni parcijalni agonist D1/D5 receptora.[5] On ima stimulansno i anoreksičko dejstvo.[6][7]

Reference[uredi | uredi kod]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Dubois A, Savasta M, Curet O, Scatton B (September 1986). „Autoradiographic distribution of the D1 agonist [3HSKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors”]. Neuroscience 19 (1): 125–37. DOI:10.1016/0306-4522(86)90010-2. PMID 2946980. 
  6. Trampus M, Ferri N, Adami M, Ongini E (April 1993). „The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat”. European Journal of Pharmacology 235 (1): 83–7. DOI:10.1016/0014-2999(93)90823-Z. PMID 8100197. 
  7. Cooper SJ, Francis J, Rusk IN (1990). „The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour”. Psychopharmacology 100 (2): 182–7. DOI:10.1007/BF02244403. PMID 1968277. 

Spoljašnje veze[uredi | uredi kod]


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