SKF-38393

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SKF-38393
(IUPAC) ime
1-fenil-2,3,4,5-tetrahidro-1H-3-benzazepin-7,8-diol
Klinički podaci
Identifikatori
CAS broj 67287-49-4
ATC kod nije dodeljen
PubChem[1][2] 1242
ChemSpider[3] 1205
ChEMBL[4] CHEMBL24077 YesY
Hemijski podaci
Formula C16H17NO2 
Mol. masa 255,31 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

SKF-38393 je sintetičko jedinjenje iz benzazepinske hemijske klase koje deluje kao selektivni parcijalni agonist D1/D5 receptora.[5] On ima stimulansno i anoreksičko dejstvo.[6][7]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. Dubois A, Savasta M, Curet O, Scatton B (September 1986). "Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors". Neuroscience 19 (1): 125–37. PMID 2946980. doi:10.1016/0306-4522(86)90010-2. 
  6. Trampus M, Ferri N, Adami M, Ongini E (April 1993). "The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat". European Journal of Pharmacology 235 (1): 83–7. PMID 8100197. doi:10.1016/0014-2999(93)90823-Z. 
  7. Cooper SJ, Francis J, Rusk IN (1990). "The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour". Psychopharmacology 100 (2): 182–7. PMID 1968277. doi:10.1007/BF02244403. 

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