Tedatioksetin

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Tedatioksetin
(IUPAC) ime
4-{2-[(4-metilfenil)sulfanil]fenil}piperidin
Klinički podaci
Identifikatori
CAS broj 508233-95-2
ATC kod nije dodeljen
PubChem[1][2] 9878913
ChemSpider[3] 8054590
KEGG[4] D10170 YesY
Hemijski podaci
Formula C18H21NS 
Mol. masa 283,43 g/mol
SMILES eMolekuli & PubHem
Sinonimi Lu AA24530; Lu-AA-24530
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Investigational

Tedatioksetin (Lu AA24530) je antidepresiv koji je u razvoju za tretman kliničke depresije (MDD).[5][6] Tedatioksetin deluje kao trostruki inhibitor preuzimanja (5-HT > NE > DA). On je isto tako antagonist na 5-HT2A, 5-HT2C, 5-HT3 i α1A-adrenergičkim receptorima.Greška kod citiranja: Nevaljana oznaka <ref>; nevaljani nazivi, npr. možda ih je previše[7][8][9][10]

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Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. "Pipeline". http://investor.lundbeck.com/pipeline.cfm. pristupljeno 4. 10. 2012.. 
  6. "Search of: Lu AA24530 - List Results - ClinicalTrials.gov". http://clinicaltrials.gov/ct2/results?term=Lu+AA24530. 
  7. Stahl, Stephen M. (19. 5. 2008.). Depression and bipolar disorder: Stahl's essential psychopharmacology. Cambridge University Press. str. 206. ISBN 978-0-521-88663-5. http://books.google.com/books?id=zqvVZOea2JAC&pg=PA206. pristupljeno 22 November 2011. 
  8. Stolerman, Ian P. (30. 8. 2010.). Encyclopedia of Psychopharmacology. Springer. str. 105. ISBN 978-3-540-68698-9. http://books.google.com/books?id=qoyYobgX0uwC&pg=PA105. pristupljeno 22 November 2011. 
  9. "Lu AA24530 shows positive results in major depressive disorder phase II study - FierceBiotech". http://www.fiercebiotech.com/press-releases/lu-aa24530-shows-positive-results-major-depressive-disorder-phase-ii-study. 
  10. "Future Treatments for Depression, Anxiety, Sleep Disorders, Psychosis, and ADHD -- Neurotransmitter.net". http://www.neurotransmitter.net/newdrugs.html. 

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