CP-809,101

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CP-809,101
(IUPAC) ime
2-[(3-Hlorofenil)metoksi]-6-(1-piperazinil)pirazin
Klinički podaci
Identifikatori
CAS broj 479683-64-2
ATC kod nije dodeljen
Hemijski podaci
Formula C15H17ClN4O 
Mol. masa 304,774 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

CP-809,101 je lek koji deluje kao potentan i selektivan agonist 5-HT2C receptora.[1] On je proizveo obećavajuće rezultate u životinjskim modelima gojaznosti i psihoze, ali isto tako uzrokuje genotoksičnost, te je njegova upotreba ograničena na naučna istraživanja.[2][3]

Reference[uredi - уреди | uredi izvor]

  1. Strong PV, Greenwood BN, Fleshner M (May 2009). "The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats". Psychopharmacology 203 (4): 665–75. PMID 19037632. doi:10.1007/s00213-008-1413-3. 
  2. Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA (February 2007). "CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity". Neuropharmacology 52 (2): 279–90. PMID 16949622. doi:10.1016/j.neuropharm.2006.07.024. 
  3. Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K (June 2007). "Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation". Drug Metabolism and Disposition: the Biological Fate of Chemicals 35 (6): 848–58. PMID 17344339. doi:10.1124/dmd.106.013649. 

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