RS-67333

RS-67333
(IUPAC) ime
	1-(4-amino-5-hloro-2-metoksifenil)-3-(1-butil-4-piperidinil)-1-propanon
Klinički podaci
Identifikatori
CAS broj	160845-95-4
ATC kod	nije dodeljen
Hemijski podaci
Formula	C19H29N2O2
Mol. masa	352,9 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H29ClN2O2/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2/h12-14H,3-11,21H2,1-2H3 ; Key: JBHLYIVFFLNISJ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

RS-67,333 je psihoaktivni lek i istraživačka hemikalija koja se ispituje kao potencijalni brzo delujući antidepresiv,^[1] nootropik,^[2] i tretman za Alchajmerovu bolest.^[3] On ima parcijalni agonist visokog afiniteta za 5-HT₄ receptor, kao i ligand za sigma receptor sa preferencijom za σ₁ tip.^[4]

Reference[uredi | uredi kod]

↑ Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G. (2007). „Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action.”. Neuron. 55 (5): 712–25. DOI:10.1016/j.neuron.2007.07.041. PMID 17785179.
↑ Lamirault L, Simon H. (2001). „Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors.”. Neuropharmacology. 41 (7): 844–53. DOI:10.1016/S0028-3908(01)00123-X. PMID 11684148.
↑ Cho S, Hu Y. (2007). „Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival.”. Experimental Neurology 203 (1): 274–8. DOI:10.1016/j.expneurol.2006.07.021. PMID 16978609.
↑ Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD (August 1995). „Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo”. Br. J. Pharmacol. 115 (8): 1387–92. PMC 1908873. PMID 8564196.

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