Dihidroergotamin

Dihidroergotamin
(IUPAC) ime
	(2R,4R,7R)-N-[(1S,2S,4R,7S)-7-benzil-2-hidroksi-4-metil-5,8-diokso-3-oksa-6,9-diazatriciklo[7.3.0.02,6]dodekan-4-yl]-6-metil-6,11-diazatetraciklo[7.6.1.02,7.012,16]heksadeka-1(16),9,12,14-tetraen-4-karboksamid
Klinički podaci
Robne marke	D.H.E. 45, Migranal
AHFS/Drugs.com	Monografija
MedlinePlus	a603022
Identifikatori
CAS broj	511-12-6
ATC kod	N02CA01
PubChem	10531
DrugBank	DB00320
ChemSpider	10091
UNII	436O5HM03C
KEGG	D07837
ChEBI	CHEBI:4562
ChEMBL	CHEMBL1732
Hemijski podaci
Formula	C33H37N5O5
Mol. masa	583,678 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C33H37N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39)/t21-,23-,25-,26+,27+,32-,33+/m1/s1 ; Key: LUZRJRNZXALNLM-JGRZULCMSA-N
Sinonimi	(5'α)-9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-ergotaman-3',6',18-trione
Farmakokinetički podaci
Poluvreme eliminacije	9 sati
Izlučivanje	Žuč
Farmakoinformacioni podaci
Licenca	US FDA:link
Trudnoća	X(US)
Pravni status	℞-only (SAD)
Način primene	Nazalni sprej, SC, IM, IV

Dihidroergotamin (D.H.E. 45, Migranal) je ergotni alkaloid koji je korišten za tretiranje migrena. On je derivat ergotamina. On se dozira kao nazalni sprej ili injekcija i ima efikasnost sličnu sumatriptanu. Mučnina je česta nuspojava.^[6]

Dihidroergotamin ima sličan način dejstvo sa triptanima. On je agonist serotoninskog 5-HT(1D) receptora i uzrokuje vazokonstrikciju intrakranijalnih krvnih sudova, ali isto tako formira interakcije sa dopaminskim i adrenergičkim receptorima u CNS-u. On se može koristiti za tretiranje akutnih glavobolja ili simptoma povlačenje nakon upotrebe analgetika.

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Colman, Ian; Brown, Michael D., Innes, Grant D., Grafstein, Eric, Roberts, Ted E., Rowe, Brian H. (2005-04-01). „Parenteral Dihydroergotamine for Acute Migraine Headache: A Systematic Review of the Literature”. Annals of Emergency Medicine 45 (4): 393–401. DOI:10.1016/j.annemergmed.2004.07.430. PMID 15795718.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Colman-6] Colman, Ian; Brown, Michael D., Innes, Grant D., Grafstein, Eric, Roberts, Ted E., Rowe, Brian H. (2005-04-01). „Parenteral Dihydroergotamine for Acute Migraine Headache: A Systematic Review of the Literature”. Annals of Emergency Medicine 45 (4): 393–401. DOI:10.1016/j.annemergmed.2004.07.430. PMID 15795718.

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Dihidroergotamin

Reference[uredi | uredi kod]

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