Melperon

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Melperon
(IUPAC) ime
1-(4-fluorofenil)-4-(4-metil-1-piperidil)butan-1-on
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 3575-80-2
ATC kod N05AD03
PubChem[1][2] 15387
ChemSpider[3] 14646
UNII J8WA3K39B7 YesY
KEGG[4] D07309 YesY
Hemijski podaci
Formula C16H22FNO 
Mol. masa 263,35 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Metabolizam Hepatički (inhibira CYP2D6[5])
Poluvreme eliminacije 3–4 časa (oralno)
6 časova (intramuskularno)
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Oralno, intramuskularna injekcija

Melperon (Buronil, Burnil, Eunerpan) je atipični antipsihotik iz butirofenonske hemijske klase.

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Grözinger M, Dragicevic A, Hiemke C, Shams M, Müller MJ, Härtter S (2003). "Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine". Pharmacopsychiatry 36 (1): 3–6. PMID 12649767. doi:10.1055/s-2003-38084. 

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