Citikolin

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Citikolin
(IUPAC) ime
5'-O-[hidroksi({hidroksi[2-(trimetilamonio)etoksi]
fosforil}oksi)fosforil]citidin
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 987-78-0
ATC kod N06BX06
PubChem[1][2] 13805
ChemSpider[3] 16736209
UNII 536BQ2JVC7 YesY
KEGG[4] D00057 YesY
ChEMBL[5] CHEMBL1618340 YesY
Hemijski podaci
Formula C14H27N4O11P2+
Mol. masa 489,332 g/mol
SMILES eMolekuli & PubHem
Sinonimi Cytidine diphosphate choline
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Citikolin (citidin difosfat-holin, CDP-holin, citidin 5'-difosfoholin) je psihostimulans/nutropik. On je intermedijar u generaciji fosfatidilholina iz holina.

Ispitivanja sugerišu da CDP-holin suplementi povećavaju gustine dopaminskog receptora,[6] i da pomažu u sprečavanju gubljenja memorije uzrokovanog lošim uslovima životne sredine.[7] Preliminarna ispitivanja su utvrdila da citikolinski suplementi pomažu u poboljšanju fokusa i mentalne energije, te da potencijalno mogu da budu korisni u tretmanu deficita koncentracije.[8][9] Citikolin isto tako povišava nivo ACTH-a nezavisno od nivoa CRH.[10]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Giménez R, Raïch J, Aguilar J (November 1991). "Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice". British Journal of Pharmacology 104 (3): 575–8. PMC 1908237. PMID 1839138. 
  7. Teather LA, Wurtman RJ (2005). "Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats". Learning & Memory 12 (1): 39–43. PMC 548494. PMID 15647594. doi:10.1101/lm.83905. 
  8. "Supplement naturally boosts ageing brain power". Sydney Morning Herald. 25. 02. 2008. Pristupljeno 28. 07. 2009..  Check date values in: |date=, |accessdate= (help)
  9. Silveri MM, Dikan J, Ross AJ et al. (November 2008). "Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy". NMR in Biomedicine 21 (10): 1066–75. PMID 18816480. doi:10.1002/nbm.1281. 
  10. Cavun S, Savci V (October 2004). "CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement". Fundamental & Clinical Pharmacology 18 (5): 513–23. PMID 15482372. doi:10.1111/j.1472-8206.2004.00272.x. 

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