Aceklidin

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Aceklidin
(IUPAC) ime
1-azabiciklo[2.2.2]oct-3-il acetat
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 827-61-2
6109-70-2 (HCl)
ATC kod S01EB08
PubChem[1][2] 1979
ChemSpider[3] 1902
UNII 0578K3ELIO YesY
KEGG[4] D02750 YesY
ChEMBL[5] CHEMBL20835 YesY
Hemijski podaci
Formula C9H15NO2 
Mol. masa 169,221 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Prescription only
Način primene Ocularno

Aceklidin (Glaukostat, Glaunorm, Glaudin) je parasimpatomimetički miotički agens koji se koristi za tretiranje glaukoma uskog ugla. On umanjuje intraokularni pritisak.

Nepoželjna dejstva[uredi - уреди | uredi izvor]

Nepoželjna dejstva aceklidina su povećana salivacija i bradikardija (pri primeni prekomernih doza).

Mehanizam dejstva[uredi - уреди | uredi izvor]

Aceklidin deluje kao agonist muskarinskog acetilholinskog receptora.[6]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Shannon HE, Hart JC, Bymaster FP et al. (August 1999). "Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats". J. Pharmacol. Exp. Ther. 290 (2): 901–7. PMID 10411607. 

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