Holin

Holin
	2-Hidroksi-N,N,N-trimetiletanaminijum
Drugi nazivi	Bilinurin, (2-Hidroksietil)trimetilamonijum
Identifikacija
CAS registarski broj	62–49–7
PubChem	6209
ChemSpider	299
UNII	N91BDP6H0X
EC-broj	200–655–4
DrugBank	DB00122
KEGG	C00114
ChEBI	15354
ChEMBL	CHEMBL920
Bajlštajn	1736748
Gmelin Referenca	324597
Jmol-3D slike	Slika 1
SMILES
	C[N+](C)(C)CCO
InChI
	InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 ; Kod: OEYIOHPDSNJKLS-UHFFFAOYSA-N InChI=InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1
Svojstva
Molekulska formula	C5H14NO
Molarna masa	104,17080
Gustina	1,09 g/ml
Tačka ključanja	305 °C, 578 K, 581 °F
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Holin je u vodi rastvoran esencijalni nutrijent.^[6]^[7]^[8]^[9] On se obično svrstava u B-kompleks vitamina. Holin se normalno javlja u obliku raznih kvaternarnih amonijum soli koje sadrže N,N,N-trimetiletanolamonijum katjon.

Katjon holina se javlja kao čeona grupa fosfatidilholina i sfingomijelina, dve klase fosfolipida koje su široko rasprostranjene u ćelijskim membranama. Holin je prekursorni molekul za neurotransmiter acetilholin koji ima veliki broj funkcija, kao što su memorija i kontrola mišića.

Holin se mora uneti putem hrane da bi telo ostalo zdravo.^[10] On se koristi u sintezi gradivnih komponenti ćelijskih membrana.^[11]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Jane Higdon, "Choline", Micronutrient Information Center, Linus Pauling Institute, Oregon State University
↑ Zeisel SH, da Costa KA (November 2009). „Choline: an essential nutrient for public health”. Nutrition Reviews 67 (11): 615–23. DOI:10.1111/j.1753-4887.2009.00246.x. PMC 2782876. PMID 19906248.
↑ "Choline" (An interview with Steven Zeisel, Editor-in-Chief of the Journal of Nutritional Biochemistry), Radio National Health Report with Norman Swan, Monday 17 April 2000
↑ "[1]" Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B₆, Folate, Vitamin B₁₂, Pantothenic Acid, Biotin, and Choline (1998), Institute of Medicine.
↑ Choline (at Linus Paulin Inst)
↑ AJCN 92 n5: 1113-1119 (Nov 2010)

Povezano

Spoljašnje veze

Portal Hemija

Holin, Linus Poling Institut
Holin, Kjoto enciklopedija gena i genoma

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Jane Higdon, "Choline", Micronutrient Information Center, Linus Pauling Institute, Oregon State University

[Zeisel_SH,_da_Costa_KA_2009_615–23-7] Zeisel SH, da Costa KA (November 2009). „Choline: an essential nutrient for public health”. Nutrition Reviews 67 (11): 615–23. DOI:10.1111/j.1753-4887.2009.00246.x. PMC 2782876. PMID 19906248.

[8] "Choline" (An interview with Steven Zeisel, Editor-in-Chief of the Journal of Nutritional Biochemistry), Radio National Health Report with Norman Swan, Monday 17 April 2000

[9] "[1]" Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B₆, Folate, Vitamin B₁₂, Pantothenic Acid, Biotin, and Choline (1998), Institute of Medicine.

[10] Choline (at Linus Paulin Inst)

[11] AJCN 92 n5: 1113-1119 (Nov 2010)

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