Menatetrenon

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Menatetrenon
(IUPAC) ime
2-metil-3-[(2Z,6E,10E)-3,7,11,15-tetrametilheksadeka-2,6,10,14-tetraen-1-il]naftohinon
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 863-61-6
ATC kod nije dodeljen
PubChem[1][2] 5282367
UNII 27Y876D139 YesY
KEGG[3] D00100 YesY
Hemijski podaci
Formula C31H40O2 
Mol. masa 444,648 g/mol
SMILES eMolekuli & PubHem
Sinonimi 3-metil-2-[(2Z,6E,10E)-3,7,11,15-tetrametilheksadeka-2,6,10,14-tetraenil]naftalen-1,4-dion
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Oralno

Menatetrenon (MK4) je menahinonsko jedinjenje koji se koristi kao hemostatički agens i kao dopunska terapija za bol uzrokovan osteoporozom. On je u prodaji za tu tretman osteoporoze u Japanu pod imenom Glakaj.

Menatetrenon jedna od devet formi vitamina K2.[4]

MK4 se formira konverzijom vitamina K1 u telu, testisima, pankreasu i arterijskim zidovima.[5] Mada biohemijski put transformacije vitamina K1 u MK4 nije potpuno razjašnjen, studije sugerišu da konverzija nije zavisna od bakterija u crevima.[6][7][8][9] Tkiva koja akumuliraju velike količine MK4 imaju veliki kapacitet konvertovanja dostupnog K1 u MK4.[10][11]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  4. Iwamoto J, Takeda T, Sato Y (December 2006). "Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis". Nutr. Rev. 64 (12): 509–17. PMID 17274493. doi:10.1111/j.1753-4887.2006.tb00184.x. 
  5. Shearer, Shearer MJ; Newman P. (2008). "Metabolism and cell biology of vitamin K". Thrombosis and Haemostasis: 530–547. doi:10.1160/TH08-03-0147. 
  6. Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). "Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria1". Journal of Nutrition 128 (2): 220–223. PMID 9446847. 
  7. Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW. (1998). "Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat". Biochimica et Biophysica Acta (BBA) - General Subjects 1379 (1): 69–75. PMID 9468334. doi:10.1016/S0304-4165(97)00089-5. 
  8. Thijssen, HHW; Drittij-Reijnders MJ (1994). "Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4". British Journal of Nutrition 72 (3): 415–425. PMID 7947656. doi:10.1079/BJN19940043. 
  9. Will, BH; Usui Y, Suttie JW (1992). "Comparative Metabolism and Requirement of Vitamin K in Chicks and Rats". Journal of Nutrition 122 (12): 2354–2360. PMID 1453219. 
  10. Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). "Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria". Journal of Nutrition 128 (2): 220–223. PMID 9446847. 
  11. Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW (1998). "Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat". Biochimica et Biophysica Acta (BBA) - General Subjects 1379 (1): 69–75. PMID 9468334. doi:10.1016/S0304-4165(97)00089-5. 

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