Menatetrenon (MK4) je menahinonsko jedinjenje koji se koristi kao hemostatički agens i kao dopunska terapija za bol uzrokovan osteoporozom. On je u prodaji za tu tretman osteoporoze u Japanu pod imenom Glakaj.
MK4 se formira konverzijom vitamina K1 u telu, testisima, pankreasu i arterijskim zidovima.[5] Mada biohemijski put transformacije vitamina K1 u MK4 nije potpuno razjašnjen, studije sugerišu da konverzija nije zavisna od bakterija u crevima.[6][7][8][9] Tkiva koja akumuliraju velike količine MK4 imaju veliki kapacitet konvertovanja dostupnog K1 u MK4.[10][11]
↑Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑Shearer, Shearer MJ; Newman P. (2008). „Metabolism and cell biology of vitamin K”. Thrombosis and Haemostasis: 530–547. DOI:10.1160/TH08-03-0147.
↑Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). „Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria1”. Journal of Nutrition128 (2): 220–223. PMID9446847.
↑Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW. (1998). „Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat”. Biochimica et Biophysica Acta (BBA) - General Subjects1379 (1): 69–75. DOI:10.1016/S0304-4165(97)00089-5. PMID9468334.
↑Thijssen, HHW; Drittij-Reijnders MJ (1994). „Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4”. British Journal of Nutrition72 (3): 415–425. DOI:10.1079/BJN19940043. PMID7947656.
↑Will, BH; Usui Y, Suttie JW (1992). „Comparative Metabolism and Requirement of Vitamin K in Chicks and Rats”. Journal of Nutrition122 (12): 2354–2360. PMID1453219.
↑Davidson, RT; Foley AL, Engelke JA, Suttie JW (1998). „Conversion of Dietary Phylloquinone to Tissue Menaquinone-4 in Rats is Not Dependent on Gut Bacteria”. Journal of Nutrition128 (2): 220–223. PMID9446847.
↑Ronden, JE; Drittij-Reijnders M-J, Vermeer C, Thijssen HHW (1998). „Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat”. Biochimica et Biophysica Acta (BBA) - General Subjects1379 (1): 69–75. DOI:10.1016/S0304-4165(97)00089-5. PMID9468334.