Pantenol

Pantenol
	2,4-Dihidroksi-N-(3-hidroksipropil)-3,3-dimetilbutanamid
Identifikacija
CAS registarski broj	16485-10-2 , 81-13-0 R
PubChem	4678, ; 131204 R, ; 5748487 S
ChemSpider	4516 , 115991 R , 4677984 S
UNII	1O6C93RI7Z
EINECS broj	240-540-6
KEGG	D03726
MeSH	dexpanthenol
ChEBI	27373
ChEMBL	CHEMBL1200979
RTECS registarski broj toksičnosti	ES4316500
ATC code	A11HA30,D03AX03, S01XA12
Bajlštajn	1724945, 1724947 R
3DMet	B00882
Jmol-3D slike	Slika 1; Slika 2
SMILES
	CC(C)(CO)C(O)c(:[o]):[nH]CCCO CC(C)(CO)C(O)C(=O)NCCCO
InChI
	InChI=1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14) ; Kod: SNPLKNRPJHDVJA-UHFFFAOYSA-N
Svojstva
Molekulska formula	C9H19NO4
Molarna masa	205.25 g mol−1
Agregatno stanje	Bezbojna tečnost
Gustina	1,2 g mL−1 (na 20 °C)
Tačka topljenja	66-69 °C, 339-342 K, 151-156 °F
log P	−0,989
pKa	13,033
Baznost (pKb)	0,964
Indeks prelamanja (nD)	1,499
Opasnost
LD50	10,100 mg kg−1 (intraperitonealno, miš)
Srodna jedinjenja
Srodna jedinjenja	Arginin; Teanin; Pantotenska kiselina; Hopantenska kiselina;
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Pantenol je alkoholni analog pantotenske kiseline (vitamina B₅), i stoga je provitamin B₅. U organizmima se brzo oksidizuje do pantotenata. Pantenol je veoma viskozna transparentna tečnost na sobnoj temperaturi, dok su soli pantotenske kiseline (na primer natrijum pantotenat) tipično beli prahovi. On je rastvoran u vodi, alkoholu i propilen glikolu, kao ietru i hloroformu, i u maloj meri u glicerinu.

Pantenol ima dva enantiomera, D i L. Samo je D-pantenol (dekspantenol) biološki aktivan, međutim obe forme imaju sposobnost ovlažavanja. Za kozmetičku upotrebu, pantenol može da u bilo D formi, ili kao racemska smeša D i L (DL-pantenol).

Reference

↑ „Dexpanthenol - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005.. Identificaion. Pristupljeno 29. 6. 2012.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

Spoljašnje veze

Portal Hemija

[1] „Dexpanthenol - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005.. Identificaion. Pristupljeno 29. 6. 2012.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[6] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

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