A-84,543

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A-84,543
(IUPAC) ime
3-(1-metil-2-(S)-pirolidinilmetokdi)piridin
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 9794141
ChemSpider[3] 10739566
ChEMBL[4] CHEMBLCHEMBL84149 YesY
Hemijski podaci
Formula C11H16N2O 
Mol. masa 192,257
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

A-84543 je lek koji je razvilo preduzeće Abbott. Ovaj molekul je agonist neuronskog nikotinskog acetilholinskog receptora koji je visoko selektivan za α4β2 receptor. On nalazi široku primenu u naučnim israživanjima strukture i funkcije tog receptora. Ovaj ligand je bio polazno jedinjenje u razvoji velike familije srodnih derivata.[5][6][7][8]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. Abreo, M.; Lin, N.; Garvey, D.; Gunn, D.; Hettinger, A.; Wasicak, J.; Pavlik, P.; Martin, Y.; Donnelly-Roberts, D. (1996). "Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors". Journal of Medical Chemistry 39 (4): 817–825. PMID 8632405. doi:10.1021/jm9506884. 
  6. Lin, N. H.; Gunn, D. E.; Li, Y.; He, Y.; Bai, H.; Ryther, K. B.; Kuntzweiler, T.; Donnelly-Roberts, D. L.; Anderson, D. J. (1998). "Synthesis and structure-activity relationships of pyridine-modified analogs of 3-2-((S)-pyrrolidinyl)methoxypyridine, A-84543, a potent nicotinic acetylcholine receptor agonist". Bioorganic & Medicinal Chemistry Letters 8 (3): 249–254. PMID 9871663. doi:10.1016/S0960-894X(98)00019-5. 
  7. Wei, Z.; Xiao, Y.; Yuan, H.; Baydyuk, M.; Petukhov, P.; Musachio, J.; Kellar, K.; Kozikowski, A. (2005). "Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits". Journal of Medicinal Chemistry 48 (6): 1721–1724. PMID 15771418. doi:10.1021/jm0492406. 
  8. Carreras, J.; Avenoza, A.; Busto, J.; Peregrina, J. (2007). "Synthesis of azabicyclo2.2.nalkane systems as analogues of 3-1-methyl-2-(S)-pyrrolidinyl- methoxypyridine (A-84543)". The Journal of Organic Chemistry 72 (8): 3112–3115. PMID 17371077. doi:10.1021/jo0700732.