Lobelin

Iz Wikipedije, slobodne enciklopedije
Lobelin
(IUPAC) ime
2-((2R,6S)-6-((S)-2-Hidroksi-2-feniletil)-1-metilpiperidin-2-il)-1-feniletanon
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 90-69-7
ATCvet kod QV04CV01
PubChem[1][2] 101616
ChemSpider[3] 91814
UNII D0P25S3P81 YesY
KEGG[4] D02364 YesY
ChEMBL[5] CHEMBL15476 YesY
Hemijski podaci
Formula C22H27NO2 
Mol. masa 337,455
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Lobelin je prirodni alkaloid prisutan u biljkama Lobelia inflata, Lobelia tupa, Lobelia cardinalis, Lobelia siphilitica, i Hippobroma longiflora. U svojoj čistoj formi on je beli amorfni prah koji je rastvoran u vodi.

Lobelin kao pomoćno sredstvo za potiskivanje želje za pušenjem,[6][7][8] a moguće je da primenljiv i kod drugih tipova zavisnosti, kao što je adikcija na amfetamin,[9][10] kokain[11] ili alkohol.[12]

Reference[uredi - уреди | uredi izvor]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  6. Stead LF, Hughes JR (2012). "Lobeline for smoking cessation". Cochrane Database Syst Rev 2: CD000124. PMID 22336780. doi:10.1002/14651858.CD000124.pub2. 
  7. Marlow SP, Stoller JK. Smoking cessation. Respiratory Care. 2003 Dec;48(12):1238-56. PMID 14651764
  8. Buchhalter AR, Fant RV, Henningfield JE. Novel pharmacological approaches for treating tobacco dependence and withdrawal : current status. Drugs. 2008;68(8):1067-88. PMID 18484799
  9. Neugebauer NM, Harrod SB, Stairs DJ, Crooks PA, Dwoskin LP, Bardo MT. Lobelane decreases methamphetamine self-administration in rats. European Journal of Pharmacology. 2007 Sep 24;571(1):33-8. DOI:10.1016/j.ejphar.2007.06.003 PMID 17612524
  10. Eyerman DJ, Yamamoto BK. Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum. Journal of Pharmacology and Experimental Therapeutics. 2005 Jan;312(1):160-9. PMID 15331654
  11. Polston JE, Cunningham CS, Rodvelt KR, Miller DK. Lobeline augments and inhibits cocaine-induced hyperactivity in rats. Life Sciences. 2006 Aug 1;79(10):981-90. PMID 16765386
  12. Farook JM, Lewis B, Gaddis JG, Littleton JM, Barron S. Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiology and Behavior. 2009 Jun 22;97(3-4):503-6. PMID 19268674